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oai:www.ideals.illinois.edu:2142/86383 2023-07-11 col_2142_5131 col_2142_16278 com_2142_5130 com_2142_16277 com_2142_9614

eng Jeff Woods Keylock, Kerry Todd 2015-09-28T15:04:24Z 2015-09-28T15:04:24Z 10000-01-01 2007 2007 This study's purpose was to determine the effect of exercise on wound healing and inflammation in young (three months) and old (18-months) female Balb/cByJ mice. Mice were assigned to either exercise (EX) or sedentary control (CON) group. EX mice were run on a motorized treadmill at a moderate intensity for 30 minutes/day for eight days, three days before wounding, and five days afterwards. Mice were given four full thickness dermal wounds using a 3.5mm punch biopsy instrument and wounds were photographed for 10 days. After the old mice fully healed (approximately 3 months), they were wounded again in different locations and wounds with surrounding tissue were harvested at one, three, or five days after wounding. Harvested wound tissue was analyzed with the Bio-Plex(TM) cytokine assay for interleukin-1 (IL-1beta), interleukin-6 (IL-6), keratinocyte chemoattractant (KC), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha). No significant differences in wound size were found as a result of exercise in young mice. However, exercise significantly decreased wound size in old mice when compared to sedentary control mice (F(1,38) = 6.33, p = .016). Levels of some proinflammatory cytokines and chemokines in wound tissue of exercised mice were significantly lower than control mice, including TNF-alpha, KC, and MCP-1. No group differences were found in IL-1beta or IL-6. These data suggest that exercise accelerates the wound healing process in old mice, which is delayed, but not young mice, which display quick healing. In addition, moderate exercise-associated decreases in levels of some inflammatory cytokines and chemokines in wound tissue were associated with faster healing. Made available in DSpace on 2015-09-28T15:04:24Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3269939.pdf: 1961703 bytes, checksum: a1eee4a8a37d2fdef72cc2064b98f6e1 (MD5) Previous issue date: 2007 Embargo set by: Seth Robbins for item 87664 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 73 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007. http://hdl.handle.net/2142/86383 (MiAaPQ)AAI3269939 Health Sciences, Recreation Aging Delays and Exercise Accelerates Wound Healing and Decreases Inflammation in Old Mice text Kinesiology and Community Health Kinesiology and Community Health University of Illinois at Urbana-Champaign Dissertation Ph.D.