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Chiba, Akira Kim, Michael Dong 2015-09-28T15:17:05Z 2015-09-28T15:17:05Z 10000-01-01 2002 2002 In addition, I demonstrated that growth cones expressing constitutively active Cdc42 that displayed guidance defects exhibited little change in their filopodial activity when compared to wild type, whereas others without guidance defects exhibited a significant increase. Moreover, the Y40C effector-loop mutation exerted little influence over filopodial activity caused by Cdc42 activation despite its ability to suppress the guidance defects of the growth cones. Collectively, these data provide evidence that Cdc42 controls filopodial activity in axonal growth cones independently of its effects on their guidance. Furthermore, my studies begin to suggest that actin reorganization alone cannot mediate proper axon outgrowth or guidance. Made available in DSpace on 2015-09-28T15:17:05Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3044138.pdf: 3998021 bytes, checksum: 75af3c67da8d8ca8e629447fc0d9e2fb (MD5) Previous issue date: 2002 Embargo set by: Seth Robbins for item 87919 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 77 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002. http://hdl.handle.net/2142/86638 (MiAaPQ)AAI3044138 eng Biology, Neuroscience Analysis of Growth Cone Signaling During Axon Development in Drosophila Melanogaster text Microbiology Microbiology University of Illinois at Urbana-Champaign Dissertation Ph.D.