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oai:www.ideals.illinois.edu:2142/86667 2023-07-11 col_2142_5131 col_2142_16338 com_2142_5130 com_2142_16337 com_2142_14793 com_2142_8903

Henry, Jonathan J. Walter, Brian Edward 2015-09-28T15:17:17Z 2015-09-28T15:17:17Z 10000-01-01 2004 2004 "From these genes, two were examined to further characterize their roles in development and transdifferentiation. The matrix metalloproteinase Xmmp-9 was found to function during migratory and morphogenetic processes during development, and it was found to be upregulated during wound healing. Psf2 codes for a factor which functions during DNA replication as a member of the GINS heterotetramer (Kubota et al., 2003), a ""sliding clamp"" involved in DNA replication. In situ hybridization revealed that Psf2 is expressed during embryonic development in a tissue-specific manner, including the optic cup and the lens. Morpholino-mediated knockdown of Psf2 resulted in dosage-dependent phenotypes which included microphthalmia, coloboma, and abnormal lens formation. Additionally, tissue manipulation experiments in conjunction with morpholino injections demonstrated intrinsic roles for Psf2 in retinal and lens development and, secondarily, during the late phase of lens induction." Made available in DSpace on 2015-09-28T15:17:17Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3131040.pdf: 9541771 bytes, checksum: 77269af0b4f51b5d3dfb1e5cc0191cea (MD5) Previous issue date: 2004 Embargo set by: Seth Robbins for item 87948 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 147 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004. http://hdl.handle.net/2142/86667 (MiAaPQ)AAI3131040 eng Biology, Zoology Molecular Profiling: Gene Expression Reveals Discrete Phases of Lens Induction and Development in Xenopus Laevis text Microbiology Microbiology University of Illinois at Urbana-Champaign Dissertation Ph.D.