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oai:www.ideals.illinois.edu:2142/86673 2023-07-11 col_2142_5131 col_2142_16338 com_2142_5130 com_2142_16337 com_2142_14793 com_2142_8903

Benjamin D. Williams Mackinnon, Alexander Craig, Jr 2015-09-28T15:17:20Z 2015-09-28T15:17:20Z 10000-01-01 2004 2004 "The third chapter describes experimental analysis of pat-4 during the morphogenesis of the excretory canal cell. By completely removing pat-4 expression from the excretory cell, I demonstrate that pat-4 is essential for the active outgrowth and complete extension of the excretory canal processes during embryogenesis and early larval development. Interestingly, ""kinase-dead"" and PH domain-disrupted forms of PAT-4/ILK support initial canal outgrowth. However, these canals frequently fail to fully extend during active canal outgrowth resulting in shortened, misshaped mature canals. These results identify a new developmental function for PAT-4/ILK in C. elegans and directly establish a role for ILK during the dynamic process of cellular morphogenesis in vivo ." Made available in DSpace on 2015-09-28T15:17:20Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3153370.pdf: 11307125 bytes, checksum: f0f2a14f71eb3cb9013b310cffb70f2b (MD5) Previous issue date: 2004 Embargo set by: Seth Robbins for item 87954 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 126 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004. http://hdl.handle.net/2142/86673 (MiAaPQ)AAI3153370 eng Biology, Cell Cloning, Phenotypic, and Experimental Analysis of Pat-4: The Caenorhabditis Elegans Homologue of Integrin -Linked Kinase text Microbiology Microbiology University of Illinois at Urbana-Champaign Dissertation Ph.D.