2026-09-22T14:55:49Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/87133 2023-07-11 col_2142_5131 col_2142_16405 com_2142_5130 com_2142_16404 com_2142_14833

Roy, Edward J. Fan, Timothy M. 2015-09-28T15:38:29Z 2015-09-28T15:38:29Z 10000-01-01 2007 2007 In addition to exploring the clinical utility of combination cytokine therapies for the treatment of cancer, our studies also investigate the molecular mechanisms which participate in the generation of peripheral CD8+CD25 + T regulatory cells. Our findings suggest that in the presence of high concentrations of TGFbeta1, strong costimulatory strength is permissive for the induction of CD8+ T cells possessing suppressor functions. Our studies also demonstrate that the adoptive transfer of peripherally-induced regulatory CD8+ T cells into recipient mice may allow for the acceleration of pulmonary metastatic disease, suggesting that CD8+ T regulatory cells are capable of antagonizing antitumor immune responses in mice bearing metastatic melanoma. The findings from these collective studies advance our understanding of how antitumor immune responses may be enhanced through cytokine manipulation strategies, and characterize the molecular signals involved in peripheral CD8+ regulatory T cell development. Made available in DSpace on 2015-09-28T15:38:29Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3269890.pdf: 4527604 bytes, checksum: e1fe982af2c8a978119fd68fa4a08f65 (MD5) Previous issue date: 2007 Embargo set by: Seth Robbins for item 88414 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 155 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007. http://hdl.handle.net/2142/87133 (MiAaPQ)AAI3269890 eng Health Sciences, Oncology The Participation of Transforming Growth Factor Beta in Tumor Immunoevasion text Veterinary Clinical Medicine Veterinary Clinical Medicine University of Illinois at Urbana-Champaign Dissertation Ph.D.