2026-09-24T15:20:37Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/87216 2023-07-11 col_2142_5131 col_2142_16508 com_2142_5130 com_2142_16507 com_2142_14793 com_2142_8903

Since DNA-induced conformational changes in estrogen receptors affected recruitment of transcriptional coregulatory proteins, we examined differential recruitment of novel proteins. One novel protein was isolated and identified by protein sequencing as TAF-I beta, a protein previously implicated in acetylation, transcription and phosphorylation. TAF-I beta not only associates with ER in a cell environment, but also inhibits acetylation of histones and ER alpha in vitro and decreases ER alpha acetylation in vivo. Therefore, TAF-I beta may alter ER-mediated transcription by changing acetylation of ER or histones or both. Taken together, these data indicate that estrogen receptors associate with a variety of regulatory proteins and that interaction with these factors is affected both by an initial interaction with DNA and further modulated by receptor conformations induced by individual ERE sequences. Nardulli, Ann M. Loven, Margaret Anne 2015-09-28T15:50:04Z 2015-09-28T15:50:04Z 10000-01-01 2002 2002 Made available in DSpace on 2015-09-28T15:50:04Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3044163.pdf: 5284461 bytes, checksum: 6bbbd30feb3e26cf95bb7324e4987c5f (MD5) Previous issue date: 2002 Embargo set by: Seth Robbins for item 88497 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 110 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002. http://hdl.handle.net/2142/87216 (MiAaPQ)AAI3044163 eng Biology, Molecular Estrogen Receptors: Interaction With Estrogen Response Elements and Estrogen Receptor-Associated Proteins text Molecular and Integrative Physiology Molecular and Integrative Physiology University of Illinois at Urbana-Champaign Dissertation Ph.D.