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oai:www.ideals.illinois.edu:2142/87238 2023-07-11 col_2142_5131 col_2142_16508 com_2142_5130 com_2142_16507 com_2142_14793 com_2142_8903

Cox, Charles L. Lee, Sang-Hun 2015-09-28T15:50:10Z 2015-09-28T15:50:10Z 10000-01-01 2005 2005 I found that VIP selectively increases the excitability of thalamic relay neurons by producing a long-lasting depolarization. These actions lead to antioscillatory actions of VIP on intrathalamic rhythmic activity (Chapter 2). The excitatory and antioscillatory actions of VIP are predominantly mediated by VPAC2 receptors, and are mediated via the cyclic AMP-dependent second messenger system (Chapter 3). In Chapter 4, I describe experiments in which peptide histidine isoleucine (PHI), a closely related peptide to VIP, produces similar actions as VIP. In the chapter 5, I extended my findings regarding VIP actions to the visual thalamus, because my earlier work focused on somatosensory thalamus. I also provide novel data regarding electrophysiological properties of thalamic neurons in dorsal TRN, putative visual TRN. My results suggest that VIP-related peptides depolarize thalamic relay neurons and these actions clearly influence intrathalamic rhythmic activities. These peptides may play a significant role in regulating information transfer through thalamocortical circuits by modulating excitability of thalamocortical neurons. Made available in DSpace on 2015-09-28T15:50:10Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3202125.pdf: 4888486 bytes, checksum: 9203baafe1bb796b0563d0edfa58778e (MD5) Previous issue date: 2005 Embargo set by: Seth Robbins for item 88519 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 161 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005. http://hdl.handle.net/2142/87238 (MiAaPQ)AAI3202125 eng Biology, Neuroscience Regulation of Thalamic Neuron Excitability and Intrathalamic Rhythms by Vasoactive Intestinal Peptide text Molecular and Integrative Physiology Molecular and Integrative Physiology University of Illinois at Urbana-Champaign Dissertation Ph.D.