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oai:www.ideals.illinois.edu:2142/87273 2023-07-11 col_2142_5131 col_2142_16508 com_2142_5130 com_2142_16507 com_2142_14793 com_2142_8903

Dawson, M. Joan Damon, Bruce Murray 2015-09-28T15:50:19Z 2015-09-28T15:50:19Z 10000-01-01 2000 2000 The second, and major, component of this thesis concerned the exercise-induced increases the 1H T2 of muscle water. The hypotheses were tested that the T2 increase results from increased intracellular volume (VI), decreased intracellular pH (pHI), and/or changes in magnetization transfer (MT) or other longitudinal relaxation mechanisms. Isolated frog gastrocnemii were treated with iodoacetate (IAA; to inhibit lactate production), NaCN (to maximize lactate production), or left untreated and then performed 60 1s/min maximal isometric contractions. The intracellular transverse relaxation time (T2,I increased more in NaCN-treated and untreated muscles than in IAA-treated muscles. The VI increase and pHI decrease were greater in NaCN-treated and untreated muscles than in IAA-treated muscles. There was no change in the MT ratio and a slight decrease in T1 following exercise. In separate experiments, V I and pHI were manipulated in non-exercising sartorii and quantitative relationships were developed between these variables and T 2,I. A multiple regression model shows that 62% of the variance in the T2,I change of exercise is accounted for by these two variables. Made available in DSpace on 2015-09-28T15:50:19Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9971061.pdf: 9401450 bytes, checksum: 75d4e5d2f3e45d2842ffb556432724f6 (MD5) Previous issue date: 2000 Embargo set by: Seth Robbins for item 88554 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 210 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2000. http://hdl.handle.net/2142/87273 (MiAaPQ)AAI9971061 eng Health Sciences, Radiology Non-Invasive Detection of Anaerobic Metabolism in Exercising Muscle Using Proton MRI text Molecular and Integrative Physiology Molecular and Integrative Physiology University of Illinois at Urbana-Champaign Dissertation Ph.D.