2026-09-20T17:19:48Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/87617 2023-07-11 col_2142_5131 col_2142_25441 com_2142_5130 com_2142_25440 com_2142_14833

Schook, Lawrence B. Butterfield, Russell James 2015-09-28T16:21:33Z 2015-09-28T16:21:33Z 10000-01-01 2001 2001 We identified 21 regions of the mouse genome that control EAE susceptibility, disease subtype, and clinical or histological disease parameters. Our results suggest that different clinical subtypes of EAE are immunogenetically distinct. In addition, the severity, duration, and day of onset are genetically controlled. Lesion characteristics and location of lesions are modulated by numerous genetic factors and can be influenced by sex. Underlying genetic differences may explain the heterogeneity in disease course and prognosis among MS patients. In light of our findings, MS genetic studies should be stratified more stringently with respect to sex, lesion characteristics, and disease subtype. Made available in DSpace on 2015-09-28T16:21:33Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3023026.pdf: 5218059 bytes, checksum: feae18d9f9c7831f2ae8a65d216da386 (MD5) Previous issue date: 2001 Embargo set by: Seth Robbins for item 88898 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 102 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001. http://hdl.handle.net/2142/87617 (MiAaPQ)AAI3023026 eng Health Sciences, Immunology Multiple Genetic Loci Control Susceptibility and Disease Characteristics in Murine Experimental Allergic Encephalomyelitis text Veterinary Pathobiology Veterinary Pathobiology University of Illinois at Urbana-Champaign Dissertation Ph.D.