2026-09-18T19:05:51Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/87624 2023-07-11 col_2142_5131 col_2142_25441 com_2142_5130 com_2142_25440 com_2142_14833

James Zachary Fillmore, Parley Dehlin 2015-09-28T16:21:37Z 2015-09-28T16:21:37Z 10000-01-01 2004 2004 We found that the composition of the adjuvant used to induce EAE had important implications on the degree of genetic susceptibility necessary to result in disease. We also found that of the many quantitative trait loci (QTL) identified to date, genetic linkages to mouse chromosomes 7 and 11 were strongly associated with susceptibility to EAE. Further, the role of sex steroid hormones and parent-of-origin effects were studied through the use of reciprocal crosses of SJL/J and BI0.S/SgMcdJ mice. We found that adult gonadal hormones selectively regulate sexually dimorphic quantitative traits observed in EAE at the clinical, histopathologic, and genetic levels. Furthermore, we identified specific genetic linkages to chromosomes 3, 4, and 7 which were dependent on the presence or absence of gonadal sex steroids. These findings help explain the important roles of sex steroid hormones in the pathogenesis of EAE. By identifying genetic linkage in the context of specific immunologic and hormonal environments we have begun the process to identify specific genetic-environmental interactions underlying susceptibility to EAE. Made available in DSpace on 2015-09-28T16:21:37Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3130916.pdf: 7209953 bytes, checksum: fa9df68b677ffcf7c7975a1a501ac3bb (MD5) Previous issue date: 2004 Embargo set by: Seth Robbins for item 88905 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 147 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004. http://hdl.handle.net/2142/87624 (MiAaPQ)AAI3130916 eng Biology, Animal Physiology Genetic and Sex Steroid Hormone Contributions to the Sexual Dimorphism in Murine Experimental Allergic Encephalomyelitis text Veterinary Pathobiology Veterinary Pathobiology University of Illinois at Urbana-Champaign Dissertation Ph.D.