2026-09-21T17:42:05Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/87747 2023-07-11 col_2142_5131 col_2142_46414 com_2142_5130 com_2142_178 com_2142_234

Nancy Sottos Li, Fang 2015-09-28T16:23:47Z 2015-09-28T16:23:47Z 10000-01-01 2007 2007 Adhesive interactions between cells in multicellular organisms play a significant role in the development and maintenance of compact tissue structures. Cell adhesion depends on specialized adhesion molecules on the cell surfaces. Recent developments studying physical and chemical properties of the adhesion molecules have provided useful information in understanding the biological functions of the molecules. This thesis reports a combined theoretical and experimental study of adhesion molecules. A theoretical model is developed to study the strength of adhesion between two planar surfaces linked via multiple adhesion bonds in parallel subject to dynamic forces. Correlations between the dynamic strength and measurable kinetic and thermodynamic properties of the molecular bond are predicted based on the model. The model is further extended to a sphere-on-plane geometry commonly used in measurements. Dynamic force spectroscopy using atomic force microscopy is implemented to measure one of the model parameter, the intrinsic off-rate, of the adhesive bonds between various cadherin constructs. Made available in DSpace on 2015-09-28T16:23:47Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3301181.pdf: 3162269 bytes, checksum: 01c59e829f2130017496e81d26d8009c (MD5) Previous issue date: 2007 Embargo set by: Seth Robbins for item 89028 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 110 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007. http://hdl.handle.net/2142/87747 (MiAaPQ)AAI3301181 eng Biophysics, General Molecular Basis of Cell Adhesion Mechanics text Theoretical and Applied Mechanics Theoretical and Applied Mechanics University of Illinois at Urbana-Champaign Dissertation Ph.D.