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Lu, Yi Nagraj, Nandini 2015-09-28T21:57:28Z 2015-09-28T21:57:28Z 10000-01-01 2010 2010 The starting point towards the development of a successful functional nucleic acid-based sensor is its isolation and this is done through in vitro selection. In vitro selection to isolate DNAzymes for Hg2+ and Cd2+ and the use of negative selections to overcome Pb 2+ interference at various stages of selection has been described in Chapter 5. Chapter 6 describes the structure-switching strategy to isolate DNA aptamers specific for endotoxins. It is anticipated that the results obtained from the current study and future characterizations will lead to the development of functional DNA sensors for endotoxins. Made available in DSpace on 2015-09-28T21:57:28Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3431021.pdf: 7157585 bytes, checksum: 5889957db8af44eef772e0882c014eaf (MD5) Previous issue date: 2010 Embargo set by: Seth Robbins for item 89173 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 208 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2010. http://hdl.handle.net/2142/87892 (MiAaPQ)AAI3431021 eng Chemistry, Inorganic Development of Functional DNA -Based Sensors and Investigations Into Their Mechanism text University of Illinois at Urbana-Champaign Dissertation Ph.D.