2026-09-20T17:08:30Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/88165 2023-07-11 col_2142_5131 col_2142_14826 com_2142_5130 com_2142_8913 com_2142_8903

Sears, Karen E. Sorensen, Daniel Wood 2015-09-29T20:49:45Z 2015-09-29T20:49:45Z 2017-09-30T09:15:18Z 2015-08 2015-07-07 From 1957 to 1962, Thalidomide was prescribed to pregnant women as an antiemetic and was later discovered to cause serious birth defects. Thalidomide is currently being prescribed to treat erythema nodosum leprosum and multiple melanoma, and is being considered for other anti-angiogenic applications. This is of concern, as the mechanisms by which thalidomide disrupts development remain largely unknown. This lack of knowledge is largely due to the absence of an appropriate model mammalian system. Traditional mammal models, such as rats and mice, are resistant to the teratogenic properties of thalidomide. We propose to develop the gray short-tailed opossum (Monodelphis domestica) as a novel mammalian to study thalidomide teratogenesis. In M. domestica we have successfully recreated most morphological defects found in human thalidomide victims. Through RNA sequencing, we have also identified two gene that may play a significant role in the mechanism of thalidomide induced birth defects. Submission published under a 24 month embargo labeled 'U of I only', the embargo will last until 2017-08-01 The student, Daniel Sorensen, accepted the attached license on 2015-07-07 at 09:55. The student, Daniel Sorensen, submitted this Thesis for approval on 2015-07-07 at 10:01. This Thesis was approved for publication on 2015-07-07 at 11:12. DSpace SAF Submission Ingestion Package generated from Vireo submission #8361 on 2015-09-29 at 14:59:11 Made available in DSpace on 2015-09-29T20:49:45Z (GMT). No. of bitstreams: 2 SORENSEN-THESIS-2015.pdf: 664675 bytes, checksum: ef3834250e6039df7ef8ac05089ccd85 (MD5) LICENSE.txt: 4212 bytes, checksum: 9562bda8dd646ed0cea71c24bb181a41 (MD5) Previous issue date: 2015-07-07 Embargo set by: Seth Robbins for item 89445 Lift date: 2017-09-29T20:50:34Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system U of I Only Restriction Lifted for Item 89445 on 2017-09-30T09:15:18Z. application/pdf http://hdl.handle.net/2142/88165 en Copyright 2015 Daniel Sorensen Thalidomide Monodelphis Thalidomide-induced teratogenesis in gray short-tailed opossums (Monodelphis domestica) text text 2015-8 School of Integrative Biology Biology University of Illinois at Urbana-Champaign Thesis M.S.