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oai:www.ideals.illinois.edu:2142/88244 2023-07-11 col_2142_5131 col_2142_5163 com_2142_5130 com_2142_5162 com_2142_234

Popescu, Gabriel Popescu, Gabriel Kajdacsy-Balla, André Bhargava, Rohit Boppart, Stephen A. Sridharan, Shamira 2015-09-29T21:02:47Z 2015-09-29T21:02:47Z 2017-09-30T09:15:32Z 2015-08 2015-07-15 Prostate cancers, which account for 14% of all cancers diagnosed in the United States, and colorectal cancers, which account for 8.2% of all cancers, present a unique set of diagnostic problems [1]. In the case of prostate cancer, overdiagnosis of early-stage disease and poor accuracy at characterizing high-risk disease, especially when diagnosed at the intermediate stage, are major problems. A new prognostic method is thus necessary for improving prostate cancer management. In the case of colorectal cancer, early disease diagnosis is of critical importance for the purpose of reduction in disease-specific death rates. An automated screening tool which identifies cases that warrant further examination by the pathologist would assist in the implementation of a wide-spread screening program. Quantitative phase imaging (QPI) of unstained tissue provides information on the refractive index distribution, or tissue morphology, with nanometer level sensitivity. Subtle morphological changes in both the epithelial and stromal regions of tissue, which are not visible in stained tissue sections used in current pathological settings, can be measured using QPI. Thus QPI would be a valuable addition to current diagnostic pathology. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-08-01 The student, Shamira Sridharan, accepted the attached license on 2015-06-02 at 13:12. The student, Shamira Sridharan, submitted this Dissertation for approval on 2015-06-02 at 13:17. This Dissertation was approved for publication on 2015-07-15 at 07:49. DSpace SAF Submission Ingestion Package generated from Vireo submission #8255 on 2015-09-29 at 15:05:09 Made available in DSpace on 2015-09-29T21:02:47Z (GMT). No. of bitstreams: 2 SRIDHARAN-DISSERTATION-2015.pdf: 5425022 bytes, checksum: 12156e6ad9fccbabac41b84679b8be6f (MD5) LICENSE.txt: 4214 bytes, checksum: 3524e9a1105b135f22df95502f5c261f (MD5) Previous issue date: 2015-07-15 Embargo set by: Seth Robbins for item 89524 Lift date: 2017-09-29T21:03:28Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 89524 Lift date: 2017-09-29T21:08:35Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 89524 on 2017-09-30T09:15:32Z. application/pdf http://hdl.handle.net/2142/88244 en Copyright 2015 Shamira Sridharan quantitative phase imaging (QPI) phase contrast quantitative diagnosis biomarker prostate cancer colorectal cancer recurrence scattering anisotropy Applications of quantitative phase imaging for pathology text text 2015-8 Bioengineering Bioengineering University of Illinois at Urbana-Champaign Dissertation Ph.D.