2026-09-20T15:06:04Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/88319 2023-07-11 col_2142_5131 col_2142_14837 com_2142_5130 com_2142_14836 com_2142_234

Meng, Ling Jian Lai, Xiaochun 2015-09-29T21:08:26Z 2015-09-29T21:08:26Z 2017-09-30T09:15:18Z 2015-08 2015-07-23 In this work, we will evaluate a novel design of the second-generation MRI compatible SPECT system, MRC-SPECT-II, based on an inverted compound eye (ICE) gamma camera concept inspired by compound eyes often found in small invertebrates. The MRC-SPECT II system is constructed with a total of 24 ICE-camera panels that consists of a very large number (up to 1500) of independent micro-pinhole-gamma-camera-elements (MCEs) looking at the object. Each MCE only covers a narrow view angular through the object space. This system design offers several unique advantages for the MR-compatible SPECT imaging application. First, this design allows for a greatly improved system sensitivity over the more conventional pinhole SPECT system designs. Our Monte Carlo study showed that the MRC-SPECT-II system could deliver a peak geometry efficiency of around 1.5% (as compared to the typical levels of 0.1%-0.01% found in modern pre-clinical SPECT instrumentations), while maintaining an excellent spatial resolution of around 0.5 mm and a single-position field-of-view (FOV) of 1 cm. Second, the ICE camera design also allows for an ultra-compact detection system that helps to fit the MRC-SPECT-II system inside most of high-field pre-clinical MR system. Furthermore, given the very large number of micro-camera-elements pointing towards the object, the MRC-SPECT-II system design offers a super-rich angular sampling of the object. Finally, an ICE-camera-based SPECT system typically uses a highly de-magnifying geometry that requires a reduced detector volume, compared to typical pinhole SPECT system that relies on magnifying geometry to achieve a high spatial resolution. This offers the practical benefit of potentially lower construction cost. In this study, we used Monte Carlo studies to demonstrate the performance benefit of the MRC-SPECT-II system over the existing MRC-SPECT system that we have developed in our lab. We have also expanded the Monte Carlo study to evaluate the use of the ICE-SPECT concept for imaging larger objects, human brain. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-08-01 The student, Xiaochun Lai, accepted the attached license on 2015-07-23 at 10:28. The student, Xiaochun Lai, submitted this Thesis for approval on 2015-07-23 at 10:28. This Thesis was approved for publication on 2015-07-23 at 13:26. DSpace SAF Submission Ingestion Package generated from Vireo submission #8628 on 2015-09-29 at 15:06:53 Made available in DSpace on 2015-09-29T21:08:26Z (GMT). No. of bitstreams: 2 LAI-THESIS-2015.pdf: 2621856 bytes, checksum: 59d042c85ef2d352b84332767ec889de (MD5) LICENSE.txt: 4209 bytes, checksum: 82b8caf51213df8ddd49e21d51e5296f (MD5) Previous issue date: 2015-07-23 Embargo set by: Seth Robbins for item 89600 Lift date: 2017-09-29T21:08:35Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 89600 on 2017-09-30T09:15:18Z. application/pdf http://hdl.handle.net/2142/88319 en Copyright 2015 Xiaochun Lai Cadmium Telluride (CdTe) semiconductor detector single-photon emission computerized tomography (SPECT)/MRI Compound Eye Inverted compound eye camera for second generation MRI compatible SPECT system text text 2015-8 Nuclear, Plasma, & Radiological Engineering Nuclear, Plasma, & Radiolgcical Engineering University of Illinois at Urbana-Champaign Thesis M.S.