2026-09-21T21:40:09Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/88341 2023-07-11 col_2142_5131 col_2142_16338 com_2142_5130 com_2142_16337 com_2142_14793 com_2142_8903

Joanna Shisler Nichols, Daniel B. 2015-10-14T19:24:54Z 2015-10-14T19:24:54Z 10000-01-01 2008 2008 Using a series of MC160 deletion mutant proteins, we found that two distinct regions of the MC160 protein independently inhibit TNF-mediated NF-kappaB activation. Specifically, we observed that the second DED of MC160 interacts with procaspase-8 as a means to inhibit NF-kappaB activation, while the C-terminus of MC160 interacts with the chaperone Hsp90. Because both procaspase-8 and Hsp90 associate with the IKK complex, we believe that the MC160 protein binds these proteins as a means to destabilize the IKK complex, resulting in reduced IKK activation, and ultimately, inhibition of NF-kappaB activation. Made available in DSpace on 2015-10-14T19:24:54Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3347488.pdf: 8494024 bytes, checksum: 18f14a7ae09dffaac726e46640fda08b (MD5) Previous issue date: 2008 Embargo set by: Seth Robbins for item 89632 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 169 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008. http://hdl.handle.net/2142/88341 (MiAaPQ)AAI3347488 eng Biology, Virology Characterization of the Anti-Inflammatory Effects of the Molluscum Contagiosum Virus MC160 Protein text University of Illinois at Urbana-Champaign Dissertation Ph.D.