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Aksimentiev, Aleksei Selvin, Paul R. Tajkhorshid, Emad Stack, John Decker, Karl Steven 2017-09-29T16:37:49Z 2017-09-29T16:37:49Z 2017-06-02 2017-08 A detailed characterization of the physics of novel nanopore systems has the potential to revolutionize water filtration, nanofluidics, and biomolecule detection technologies. I give my characterizations of five nanopore systems as my dissertation. First, I present my study of nanopores in polyethylene terephthalate (PET), revealing the mechanism for variance in current rectification based on cation species. Second, I demonstrate the mechanism of selective probe capture in bacterial toxin protein α-hemolysin (aHL) using dielectrophoresis. Third, I introduce the first simulation of molecular artificial water channel pillar[5]arene (PAP) and uncover the mechanics of its water transport and self-aggregation properties. Fourth, I characterize the water permeability and ion rejection of truncated human membrane protein aquaporin-1 (AQP) in simulation. Finally, I present MD simulation of truncated AQP as a voltage-gated ionic diode and as the functional element of a double-membrane ionic pump. Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2017-09-29 without embargo terms The student, Karl Decker, accepted the attached license on 2017-05-31 at 14:37. The student, Karl Decker, submitted this Dissertation for approval on 2017-05-31 at 14:45. This Dissertation was approved for publication on 2017-06-02 at 10:51. DSpace SAF Submission Ingestion Package generated from Vireo submission #11189 on 2017-09-29 at 11:25:54 Made available in DSpace on 2017-09-29T16:37:49Z (GMT). No. of bitstreams: 3 DECKER-DISSERTATION-2017.pdf: 5645072 bytes, checksum: 7c18f2527c68268a4bb696a68845aa70 (MD5) LICENSE.txt: 4208 bytes, checksum: 9670dfe9964d78fcb7894dde50b725b9 (MD5) PROQUEST_LICENSE.txt: 4554 bytes, checksum: 5e4b138d07def77649e71b66315d3651 (MD5) Previous issue date: 2017-06-02 application/pdf http://hdl.handle.net/2142/98107 en Copyright 2017 Karl Decker Molecular transport Nanopore Biomolecule Ion current Filtration Selective molecular transport in nanopore systems text text Physics Physics University of Illinois at Urbana-Champaign Dissertation Ph.D.