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oai:www.ideals.illinois.edu:2142/98152 2023-07-11 col_2142_11614 col_2142_5131 com_2142_11613 com_2142_8903 com_2142_5130

Derringer, Jaime Heller, Wendy Derringer, Jaime Heller, Wendy Berenbaum, Howard Miller, Gregory A. Rudolph, Karen D. Finy, M. Sima 2017-09-29T17:45:16Z 2017-09-29T17:45:16Z 2020-03-03T10:15:18Z 2017-05-10 2017-08 Although attention-deficit/hyperactivity disorder (ADHD) is highly heritable, the processes by which genetic risk affects its development are poorly understood. Potential mechanisms that may contribute to the development of ADHD, possibly by sharing common genetic risk, include impairments in executive functions. The goal of the present study was to clarify associations among genome-wide polygenic scores, executive functions, and ADHD in a subsample of 4,226 youth to determine whether executive dysfunctions mediate the relationship between cumulative genetic risk and a dimensional trait measure of ADHD. Polygenic scores derived from genome-wide association studies of ADHD and (low) educational attainment, but not tobacco smoking, were associated with increased ADHD in a non-clinical, independent sample of youth. A common executive function factor mediated the relationship between genetic risk associated with low educational attainment and ADHD. These results demonstrate that polygenic risk for clinically-diagnosed ADHD is also associated with a dimensional trait measure of ADHD in a non-clinical sample of youth and that there is common genetic influence on risk for low educational attainment and ADHD. In addition, results demonstrate that executive dysfunction is one mechanism through which genetic variants influence ADHD and suggest that executive functions may be targets of intervention development. Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-08-01 The student, M. Finy, accepted the attached license on 2017-05-10 at 09:14. The student, M. Finy, submitted this Dissertation for approval on 2017-05-10 at 10:37. This Dissertation was approved for publication on 2017-05-10 at 12:02. DSpace SAF Submission Ingestion Package generated from Vireo submission #11151 on 2017-09-29 at 10:45:31 Made available in DSpace on 2017-09-29T17:45:16Z (GMT). No. of bitstreams: 3 FINY-DISSERTATION-2017.pdf: 1007151 bytes, checksum: f44d89a7cab83ec1cd7f73f699a00c08 (MD5) LICENSE.txt: 4208 bytes, checksum: 0feb2e0aa506f6b5eb789d87e6eae9a3 (MD5) PROQUEST_LICENSE.txt: 4554 bytes, checksum: 20890073afe162e69e99fbe9715406ad (MD5) Previous issue date: 2017-05-10 Embargo set by: Colleen Fallaw for item 103449 Lift date: 2019-09-29T17:48:06Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 103449 Lift date: 2020-03-02T19:56:41Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 103449 Lift date: 2020-03-02T19:59:52Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 103449 Lift date: 2020-03-02T20:02:46Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system U of I Only Restriction Lifted for Item 103449 on 2020-03-03T10:15:18Z. application/pdf http://hdl.handle.net/2142/98152 en Copyright 2017 M. Finy Attention-deficit/hyperactivity disorder (ADHD) Executive functions Executive dysfunction Behavior genetics Polygenic risk Genome-wide polygenic scores, executive function, and attention-deficit/hyperactivity disorder in youth text text Psychology Psychology University of Illinois at Urbana-Champaign Dissertation Ph.D.