2026-09-18T19:36:38Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/98230 2023-07-11 col_2142_5131 col_2142_14771 com_2142_5130 com_2142_685 com_2142_397

Rodriguez-Zas, Sandra Luisa Jeong, Hyeon Soo 2017-09-29T16:39:08Z 2017-09-29T16:39:08Z 2019-09-30T09:15:20Z 2017-06-12 2017-08 Migraine is a serious episodic headaches affecting more than 15% of the human population with a detrimental influence on the patients’ life and socioeconomic functioning. Although many pathophysiological and molecular mechanisms of migraine have been suggested, little is known about the molecular disruption in a chronic migraine. Here, we propose to characterize the differences of the gene expression, biological processes and pathways, and regulatory network between individuals with control and a hyperalgesia mouse model of chronic migraine. Chronic hyperalgesia was modeled using a nitroglycerin treatment. The transcriptome was characterized in the trigeminal ganglia and nucleus accumbens. Samples were sequenced using the Illumina HiSeq 4000 platform to produce paired end reads of 100 bp. Opalin, Slc32a, Cacna1b, and H2-Eb2 were among the 110 genes exhibiting significant interaction effects. The 165 genes presenting different expression patterns between the treatment and control groups included Aldh1a1 and Slc7a2. A comparative transcriptomic analysis offered insights for migraine therapies. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01 The student, Hyeon Soo Jeong, accepted the attached license on 2017-06-12 at 13:08. The student, Hyeon Soo Jeong, submitted this Thesis for approval on 2017-06-12 at 13:11. This Thesis was approved for publication on 2017-06-12 at 15:50. DSpace SAF Submission Ingestion Package generated from Vireo submission #11210 on 2017-09-29 at 11:13:36 Made available in DSpace on 2017-09-29T16:39:08Z (GMT). No. of bitstreams: 2 JEONG-THESIS-2017.pdf: 1223269 bytes, checksum: d392254d09ae667dfe58045e19e0c97e (MD5) LICENSE.txt: 4209 bytes, checksum: 5939b643b52f2a57b7f4b7667e06a3b1 (MD5) Previous issue date: 2017-06-12 Embargo set by: Colleen Fallaw for item 103377 Lift date: 2019-09-29T16:39:52Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Colleen Fallaw for item 103377 Lift date: 2019-09-29T17:52:45Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 103377 on 2019-09-30T09:15:20Z. application/pdf http://hdl.handle.net/2142/98230 en Copyright 2017 Hyeon Soo Jeong Migraine Transcriptome Hyperalgesia Neuropeptides Transcription factor Transcriptiome analysis of a migraine model text text Animal Sciences Animal Sciences University of Illinois at Urbana-Champaign Thesis M.S.