2026-09-22T02:59:29Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/98282 2023-07-11 col_2142_14789 col_2142_5131 com_2142_14788 com_2142_8903 com_2142_5130

Luthey-Schulten, Zaida Luthey-Schulten, Zaida Gruebele, Martin Ha, Taejkip Kuhlman, Thomas Lai, Jonathan 2017-09-29T16:39:47Z 2017-09-29T16:39:47Z 2019-09-30T09:15:29Z 2017-07-13 2017-08 Protein translation—the process of converting genetic information into protein chains—is one of the oldest biological processes on planet Earth. Because of its age, all organisms, after the last universal common ancestor, use the same basic components—such as the transfer RNA (tRNA); aminoacyl-tRNA synthases; and the ribosome and its various elongation, initiation, and release factors—to carry out the translation process. It is the latter group, ribosomes and associated proteins, that physically make the peptide chains. In the following thesis, we will explore the assembly and function of two components and their role in the protein synthesis. The thesis has been divided into several chapters describing (1-2) the assembly of the small subunit of the ribosome (SSU), and (3) free energy change and the mechanism of elongation factor Tu (EF-Tu). The function and evolutionary history of both components are intertwined as the SSU is responsible for decoding information encoded in messenger RNA (mRNA) and EF-Tu is responsible for delivering amino acid building blocks to the ribosome. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01 The student, Jonathan Lai, accepted the attached license on 2017-07-12 at 10:12. The student, Jonathan Lai, submitted this Dissertation for approval on 2017-07-12 at 10:16. This Dissertation was approved for publication on 2017-07-13 at 08:29. DSpace SAF Submission Ingestion Package generated from Vireo submission #11420 on 2017-09-29 at 11:19:06 Made available in DSpace on 2017-09-29T16:39:47Z (GMT). No. of bitstreams: 3 LAI-DISSERTATION-2017.pdf: 28745845 bytes, checksum: f5f7b7fe82597b730f6d1f28660771e1 (MD5) LICENSE.txt: 4209 bytes, checksum: 6fb74e0abb7d8e66d60a187e14911923 (MD5) PROQUEST_LICENSE.txt: 4555 bytes, checksum: 7e7a0c64eadfcde184c99d26ddb7de9c (MD5) Previous issue date: 2017-07-13 Embargo set by: Colleen Fallaw for item 103429 Lift date: 2019-09-29T16:39:52Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Embargo set by: Colleen Fallaw for item 103429 Lift date: 2019-09-29T17:52:45Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 103429 on 2019-09-30T09:15:29Z. application/pdf http://hdl.handle.net/2142/98282 en Copyright 2017 Jonathan Lai Molecular dynamics Translation Proteins Processes involved in protein translation text text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.