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oai:www.ideals.illinois.edu:2142/98303 2023-07-11 col_2142_14789 col_2142_5131 com_2142_14788 com_2142_8903 com_2142_5130

White, M. Christina Sookezian, Anasheh 2017-09-29T17:52:29Z 2017-09-29T17:52:29Z 2019-09-30T09:15:08Z 2017-07-19 2017-08 Reactions that directly install nitrogen into C—H bonds of complex molecules are significant due to their ability to immediately change the chemical and biological properties of a given molecule. While selective intramolecular C—H amination reactions are known, intermolecular C—H amination reactions with high reactivity and selectivity are scarce. Achieving high levels of reactivity while maintaining excellent site-selectivity and functional group tolerance remains an important challenge for intermolecular C—H amination. We report a novel manganese perchlorophthalocyanine catalyst [Mn(ClPc)] for a highly site-selective intermolecular benzylic C—H amination of bioactive molecules and natural products. [Mn(ClPc)] is selective for benzylic C—H bonds over other C—H bond types and selects among multiple benzylic C—H bonds based on their electronic and steric properties. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01 The student, Anasheh Sookezian, accepted the attached license on 2017-07-19 at 11:16. The student, Anasheh Sookezian, submitted this Thesis for approval on 2017-07-19 at 11:22. This Thesis was approved for publication on 2017-07-19 at 13:01. DSpace SAF Submission Ingestion Package generated from Vireo submission #11529 on 2017-09-29 at 11:19:55 Made available in DSpace on 2017-09-29T17:52:29Z (GMT). No. of bitstreams: 2 SOOKEZIAN-THESIS-2017.pdf: 1661977 bytes, checksum: cce9cf15d1142ee5935ea08f9415ca18 (MD5) LICENSE.txt: 4214 bytes, checksum: a3b831e109e251348e73aeccda717362 (MD5) Previous issue date: 2017-07-19 Embargo set by: Colleen Fallaw for item 103511 Lift date: 2019-09-29T17:52:45Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 103511 on 2019-09-30T09:15:08Z. application/pdf http://hdl.handle.net/2142/98303 en Copyright 2017 Anasheh Sookezian Amination Manganese C–H activation Manganese-catalyzed intermolecular benzylic C–H amination text text Chemistry Chemistry University of Illinois at Urbana-Champaign Thesis M.S.