2026-09-22T02:00:53Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/99248 2023-07-11 col_2142_5131 col_2142_14771 com_2142_5130 com_2142_685 com_2142_397

Kukekova, Anna V. Beever, Johnathan Rodriguez-Zas, Sandra Johnson, Jennifer L. 2018-03-13T15:25:33Z 2018-03-13T15:25:33Z 2020-03-14T09:15:28Z 2017-12-11 2017-12 Strains of red fox (Vulpes vulpes) with markedly different behavioral phenotypes have been developed in the famous long-term selective breeding program known as the Russian farm-fox experiment. Here we sequenced and assembled the red fox genome and re-sequenced a subset of foxes from the tame, aggressive, and conventional farm-bred populations to identify genomic regions associated with the response to selection for behavior. Analysis of the resequenced genomes identified 113 regions with either significantly decreased heterozygosity in one of the three populations or increased divergence between the populations. A strong positional candidate gene for tame behavior was highlighted: SorCS1, which encodes the main trafficking protein for AMPA glutamate receptors and neurexins and suggests a role for synaptic plasticity in fox domestication. Other regions identified as likely to have been under selection in foxes during domestication include genes implicated in human neurological disorders, in mouse behavior, and in dog domestication. The fox represents a powerful model for the genetic analysis of affiliative and aggressive behaviors that can benefit genetic studies of behavior in dogs and other mammals, including humans. Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2019-12-01 The student, Jennifer Johnson, accepted the attached license on 2017-12-07 at 09:52. The student, Jennifer Johnson, submitted this Thesis for approval on 2017-12-07 at 09:59. This Thesis was approved for publication on 2017-12-11 at 09:08. DSpace SAF Submission Ingestion Package generated from Vireo submission #11896 on 2018-03-13 at 09:57:36 Made available in DSpace on 2018-03-13T15:25:33Z (GMT). No. of bitstreams: 13 JOHNSON-THESIS-2017.pdf: 3399106 bytes, checksum: c93f52ff57ac7b5133f8a2accf541fc3 (MD5) Table_11.xlsx: 37667 bytes, checksum: c885661b7a37cafd205b21d9ab2fcf22 (MD5) Table_13.xlsx: 105404 bytes, checksum: 6b6d6a51faf155bbe2a7cb1a86660dd4 (MD5) Table_15.xlsx: 63413 bytes, checksum: c0e75a7f724f9f6e570fac1c85dd1ee4 (MD5) Table_17_1.xlsx: 38305 bytes, checksum: 7c0fb61f31247ab223f3353673575987 (MD5) Table_18.xlsx: 39903 bytes, checksum: 8aebe9b344b125f1ce4751e8ffa90ffb (MD5) Table_19.xlsx: 50348 bytes, checksum: 8ba6f0355bec6a1091f606557879f893 (MD5) Table_20.xlsx: 58194 bytes, checksum: 75ec2d9a0eca194c06dcf8f38daca469 (MD5) Table_4.xlsx: 35845 bytes, checksum: 5983f65e79f94cd1c3472567eed43790 (MD5) Table_5.xlsx: 43499 bytes, checksum: 7f70d881f8f030d274ed52c497997c84 (MD5) Table_7.xlsx: 43234 bytes, checksum: e916e882ef4001e8ae3a42435b6487ec (MD5) Table_9.xlsx: 196161 bytes, checksum: 258e5fb2001cf2ff0e3144eba3cdfb9d (MD5) LICENSE.txt: 4213 bytes, checksum: c96dfe61c1717a3773309ccc57fa6d3a (MD5) Previous issue date: 2017-12-11 Embargo set by: Seth Robbins for item 105211 Lift date: 2020-03-13T15:25:40Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system Embargo set by: Seth Robbins for item 105211 Lift date: 2020-03-13T15:28:52Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system U of I Only Restriction Lifted for Item 105211 on 2020-03-14T09:15:28Z. application/pdf http://hdl.handle.net/2142/99248 en Copyright 2017 Jennifer Johnson Genomics Bioinformatics Vulpes vulpes Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviors text text Animal Sciences Bioinformatics University of Illinois at Urbana-Champaign Thesis M.S.