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oai:www.ideals.illinois.edu:2142/99496 2023-07-11 col_2142_5131 col_2142_14828 com_2142_5130 com_2142_14827 com_2142_14793 com_2142_8903

Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-12-01 The student, Yuhang Wang, accepted the attached license on 2017-11-29 at 18:12. The student, Yuhang Wang, submitted this Dissertation for approval on 2017-11-29 at 18:17. This Dissertation was approved for publication on 2017-11-30 at 11:27. Tajkhorshid, Emad Tajkhorshid, Emad Gennis, Robert B. Grosman, Claudio Ferguson, Andrew L. Wang, Yuhang 2018-03-13T17:35:37Z 2018-03-13T17:35:37Z 2020-03-14T09:15:16Z 2017-11-30 2017-12 Membrane proteins are proteins either embedded or located at the peripheral of the biological membrane. The functions of membrane proteins include importing/exporting ions/small molecules into/output of the cell, cellular signaling, cell-cell interactions, etc. Molecular dynamics is a powerful computational tool that can provide an atomic level description of the dynamic interactions between molecules. During my Ph.D., I have studied several membrane proteins, including a membrane transporter (BetP), three ligand-gated ion channels (AMPA receptor, Glycine receptor, and GLIC), and a membrane signaling protein (human T-cell receptor). In these projects, I have uncovered key aspects of the functional mechanism of these proteins, such as active substrate transport, ion permeation, and antigen recognition. In addition, I have developed a new computational methodology for modeling the membrane protein-detergent micelles. I strongly believe that an atomic-level understanding of membrane proteins is essential to meet the challenges in biomedicine. DSpace SAF Submission Ingestion Package generated from Vireo submission #11783 on 2018-03-13 at 10:34:14 Made available in DSpace on 2018-03-13T17:35:37Z (GMT). No. of bitstreams: 6 WANG-DISSERTATION-2017.pdf: 71165000 bytes, checksum: 38c62ba5af2283e323f7a927a8d40b6e (MD5) Wang_PhD_dissertation.zip: 786947289 bytes, checksum: 612994d7d8229af5efa5da9d2e1191ff (MD5) Cell_RightsLink_Printable_License.pdf: 133478 bytes, checksum: 1ca02cb82d817c6a5f91ef4f9b24b048 (MD5) JGP_author_retain_copyright.pdf: 1045176 bytes, checksum: 6619ac8f4937c29998911a3ad48ee5a3 (MD5) LICENSE.txt: 4208 bytes, checksum: ab10b4c3d81ffd3577ea48d9a79cb04b (MD5) NatureCommunications_open_access.pdf: 67433 bytes, checksum: d10d15bd86128c9691f1d6c642b80cc3 (MD5) Previous issue date: 2017-11-30 Embargo set by: Seth Robbins for item 105465 Lift date: 2020-03-13T17:36:05Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 105465 on 2020-03-14T09:15:16Z. application/pdf http://hdl.handle.net/2142/99496 en Copyright 2017 Yuhang Wang membrane proteins, molecular dynamics, atomic level Computational characterization of membrane proteins at the atomic level text text School of Molecular & Cell Bio Biophysics & Computnl Biology University of Illinois at Urbana-Champaign Dissertation Ph.D.