University of Illinois Urbana-Champaign

Stimulated emission from biological materials and novel optical resonators for diagnostic and imaging applications

Rivera, Jose A

Content Files
RIVERA-DISSERTATION-2017.pdf

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https://hdl.handle.net/2142/97588

Description

Title
Stimulated emission from biological materials and novel optical resonators for diagnostic and imaging applications
Author(s)
Rivera, Jose A
Issue Date
2017-04-19
Director of Research (if dissertation) or Advisor (if thesis)
Eden, J. Gary
Doctoral Committee Chair(s)
Eden, J. Gary
Committee Member(s)
  • Cunningham, Brian T.
  • Insana, Michael
  • Carney, P. Scott
Department of Study
Bioengineering
Discipline
Bioengineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2017-08-10T19:52:04Z
Keyword(s)
  • Biolasers
  • Optical resonators
  • Biophotonics
  • Biosensors
  • Microlasers
Abstract
The first detailed optical characterization of any biological laser, providing spectral, temporal, threshold, and polarization characteristics for the flavin mononucleotide biomolecular laser, is presented here. In addition, our investigation of natural, bio-engineered, and complex biological laser systems culminates in the discovery of a phycobiliprotein laser, a 30% reduction in threshold energy for fluorescent protein lasers excited by circularly polarized light, and the development of a FRET-based laser using biotin-streptavidin bioconjugates comprising organic dye and gold nanoparticle donor/acceptor configurations. Furthermore, we introduce an optical resonator which can be fabricated from the directed assembly of a particle monolayer and is capable of producing hundreds or thousands of microlasers from a single pump beam. These optical resonators are based on an intra-cavity stabilization scheme which is well-suited for sensitive single-cell refractive index monitoring and intra-cavity in-line holography. Finally, we construct a microlens-stabilized microlaser array, based on a titanium doped sapphire crystal, which enables speckle-free pulsed laser imaging of biological specimens with nanosecond temporal resolution.
Graduation Semester
2017-05
Type of Resource
text
Permalink
http://hdl.handle.net/2142/97588
Copyright and License Information
Copyright 2017 Jose A. Rivera

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Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at Illinois
Dissertations and Theses - Bioengineering