Selective molecular transport in nanopore systems

Decker, Karl Steven

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https://hdl.handle.net/2142/98107 Copy

Description

Title

Selective molecular transport in nanopore systems

Author(s)

Decker, Karl Steven

Issue Date

2017-06-02

Director of Research (if dissertation) or Advisor (if thesis)

Aksimentiev, Aleksei

Doctoral Committee Chair(s)

Selvin, Paul R.

Committee Member(s)

• Tajkhorshid, Emad
• Stack, John

Department of Study

Physics

Discipline

Physics

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Date of Ingest

2017-09-29T16:37:49Z

Keyword(s)

• Molecular transport
• Nanopore
• Biomolecule
• Ion current
• Filtration

Abstract

A detailed characterization of the physics of novel nanopore systems has the potential to revolutionize water filtration, nanofluidics, and biomolecule detection technologies. I give my characterizations of five nanopore systems as my dissertation. First, I present my study of nanopores in polyethylene terephthalate (PET), revealing the mechanism for variance in current rectification based on cation species. Second, I demonstrate the mechanism of selective probe capture in bacterial toxin protein α-hemolysin (aHL) using dielectrophoresis. Third, I introduce the first simulation of molecular artificial water channel pillar[5]arene (PAP) and uncover the mechanics of its water transport and self-aggregation properties. Fourth, I characterize the water permeability and ion rejection of truncated human membrane protein aquaporin-1 (AQP) in simulation. Finally, I present MD simulation of truncated AQP as a voltage-gated ionic diode and as the functional element of a double-membrane ionic pump.

Graduation Semester

2017-08

Type of Resource

text

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http://hdl.handle.net/2142/98107

Copyright and License Information

Copyright 2017 Karl Decker

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