THE ROTATIONAL STUDY OF DOPAC, A NEURAL METABOLITE

Alonso, Elena R.

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https://hdl.handle.net/2142/100665 Copy

Description

Title

THE ROTATIONAL STUDY OF DOPAC, A NEURAL METABOLITE

Author(s)

Alonso, Elena R.

Contributor(s)

• Alonso, José L.
• Cabezas, Carlos
• Kolesniková, Lucie
• León, Iker

Issue Date

06/20/18

Keyword(s)

Conformers and isomers

Abstract

DOPAC (3,4-Dihydroxyphenylacetic acid) is an intermediate neural metabolite in the cycle of catecholamines,\footnote{ C. Cabezas, I. Peña, J. C. López and J. L. Alonso, Seven conformers of neutral dopamine revealed in the gas phase, J. Phys. Chem. Lett., 2013, 4, 486–490 and references therein.} concretely in the metabolic reaction of dopamine (DA) to produce homovanillic acid (HVA), a substance that being present in urine in a large quantity, is indicative of health problems. In this work, we present a rotational study to explore the conformational preferences of DOPAC. It has been brought into gas phase avoiding decomposition by laser ablation LA of the solid sample, and the conformers present in the supersonic expansion have been probed by CP-FTMW spectroscopy.\footnote{I. Peña, S. Mata, A. Martín, C. Cabezas, A. M. Daly and J. L. Alonso, Conformations of D-xylose: the pivotal role of the intramolecular hydrogen-bonding., Phys. Chem. Chem. Phys., 2013, 15, 18243–8.} As we will show, several conformers have been detected and characterized. All the data obtained is presented in this communication.

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

text

Language

English

Permalink

http://hdl.handle.net/2142/100665

DOI

10.15278/isms.2018.WJ01

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