Integrating inflammatory stimuli with macromolecules for therapy and sensing of vascular diseases
Leong Jiayu, Eunice
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https://hdl.handle.net/2142/102878
Description
Title
Integrating inflammatory stimuli with macromolecules for therapy and sensing of vascular diseases
Author(s)
Leong Jiayu, Eunice
Issue Date
2018-07-27
Director of Research (if dissertation) or Advisor (if thesis)
Kong, Hyunjoon
Yang, Yi Yan
Doctoral Committee Chair(s)
Kong, Hyunjoon
Committee Member(s)
Schroeder, Charles
Boppart, Marni
Department of Study
Chemical & Biomolecular Engr
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Hydrogen peroxide
nanoparticles
Abstract
Inflammation is a beneficial component for healing under normal homeostasis. However, excessive inflammation can also aggravate the patient's condition. Biochemical signals elicited under inflammatory conditions are considerably different from those under normal circumstances. Molecules such as pro-inflammatory mediator TNFα and reactive oxygen species are powerful triggers to several signaling mechanisms. In this regard, the overall goal of my research is to integrate inflammatory stimuli TNFα and ROS with macromolecules for therapy and sensing of vascular diseases. To do so, specific features of nanoparticles were studied in Chapter 2 to engineer solutions for the prevailing problems in ischemia and cancer. This thesis presents three approaches in investigating the combination of these potent inflammatory molecules with nanotechnology: (1) TNF-α-releasing liposomes were tethered on the surface of adipose-derived stem cells to enhance their secretory activities (Chapter 3). (2) Thioether-groups were incorporated into micelle-forming polymers to induce a reactive oxygen species-responsive drug release and swelling effect (Chapter 4). (3) Oxidizable chromophores were adsorbed onto support microparticles to form a hydrogen peroxide-sensing patch (Chapter 5). Overall, the results from these studies contribute to a deeper understanding of how to utilize disease biomolecules in the design of novel diagnostics and therapeutics.
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