Withdraw
Loading…
Integrating inflammatory stimuli with macromolecules for therapy and sensing of vascular diseases
Leong Jiayu, Eunice
Content Files

Loading…
Download Files
Loading…
Download Counts (All Files)
Loading…
Edit File
Loading…
Permalink
https://hdl.handle.net/2142/102878
Description
- Title
- Integrating inflammatory stimuli with macromolecules for therapy and sensing of vascular diseases
- Author(s)
- Leong Jiayu, Eunice
- Issue Date
- 2018-07-27
- Director of Research (if dissertation) or Advisor (if thesis)
- Kong, Hyunjoon
- Yang, Yi Yan
- Doctoral Committee Chair(s)
- Kong, Hyunjoon
- Committee Member(s)
- Schroeder, Charles
- Boppart, Marni
- Department of Study
- Chemical & Biomolecular Engr
- Discipline
- Chemical Engineering
- Degree Granting Institution
- University of Illinois at Urbana-Champaign
- Degree Name
- Ph.D.
- Degree Level
- Dissertation
- Date of Ingest
- 2019-02-08T18:39:36Z
- Keyword(s)
- Hydrogen peroxide
- nanoparticles
- Abstract
- Inflammation is a beneficial component for healing under normal homeostasis. However, excessive inflammation can also aggravate the patient's condition. Biochemical signals elicited under inflammatory conditions are considerably different from those under normal circumstances. Molecules such as pro-inflammatory mediator TNFα and reactive oxygen species are powerful triggers to several signaling mechanisms. In this regard, the overall goal of my research is to integrate inflammatory stimuli TNFα and ROS with macromolecules for therapy and sensing of vascular diseases. To do so, specific features of nanoparticles were studied in Chapter 2 to engineer solutions for the prevailing problems in ischemia and cancer. This thesis presents three approaches in investigating the combination of these potent inflammatory molecules with nanotechnology: (1) TNF-α-releasing liposomes were tethered on the surface of adipose-derived stem cells to enhance their secretory activities (Chapter 3). (2) Thioether-groups were incorporated into micelle-forming polymers to induce a reactive oxygen species-responsive drug release and swelling effect (Chapter 4). (3) Oxidizable chromophores were adsorbed onto support microparticles to form a hydrogen peroxide-sensing patch (Chapter 5). Overall, the results from these studies contribute to a deeper understanding of how to utilize disease biomolecules in the design of novel diagnostics and therapeutics.
- Graduation Semester
- 2018-12
- Type of Resource
- text
- Permalink
- http://hdl.handle.net/2142/102878
- Copyright and License Information
- Copyright 2018 Eunice Leong Jiayu
Owning Collections
Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at IllinoisDissertations and Theses - Chemical and Biomolecular Engineering
Dissertations and Theses - Chemical and Biomolecular EngineeringManage Files
Loading…
Edit Collection Membership
Loading…
Edit Metadata
Loading…
Edit Properties
Loading…
Embargoes
Loading…