Towards extending coarse-grained circuit-host modeling to complex environments
Sickle, Jordan
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https://hdl.handle.net/2142/106484
Description
Title
Towards extending coarse-grained circuit-host modeling to complex environments
Author(s)
Sickle, Jordan
Issue Date
2019-12-12
Director of Research (if dissertation) or Advisor (if thesis)
Lu, Ting
Department of Study
School of Molecular & Cell Bio
Discipline
Biophysics & Quant Biology
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Synthetic Biology
Mathematical Modeling
Abstract
Over the last two decades, synthetic biology has emerged as a critical toolset for genetic engineering. Synthetic gene circuits have been engineered for a variety of uses from functional modules to increasing biosynthetic yield. After decades of showing their potential in labs, synthetic circuits are about to make the leap into complex environments. Recent advances have shown that a mechanistic, coarse-grained approach can give fundamental insight into how synthetic circuits interact with their host cells, though how this model can
be applied in complex environments remains an open question. In this thesis, I will discuss how an extension of this coarse-grained model can describe circuit behavior in complex environments through mechanistic modeling of chloramphenicol and nutrient stress.
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