Red blood cells turned into squishy balls​

Ahmed, Syeda Tajin

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https://hdl.handle.net/2142/106649 Copy

Description

Title

Red blood cells turned into squishy balls​

Author(s)

Ahmed, Syeda Tajin

Issue Date

2020

Keyword(s)

Chemical and Biomolecular Engineering​

Abstract

Two fluffy ball like red blood cells are pushing onto each other via a piezo-driven micropipette (right). The surface of the red blood cells are decorated with ligands of interest (in this case, N-cadherin or Neuronal cadherin, a cell adhesion molecules). When the right pipette pulls away, adhesion causes a stretch or deformation on the cell surface. Thus, adhesion probability can be used to calculate the equilibrium receptor-ligand binding constant and binding kinetics. I have spent a lot of time looking at these squishy little balls aspirated by two micropipettes with ~3 µm diameter and learn about the binding kinetics of cell-adhesion molecules. When the plate like red blood cells swell up in hypotonic solution to form squishy ball like structure, I know I am ready to manipulate the micropipette suction pressure to pick them up!​

Type of Resource

• text
• still image

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http://hdl.handle.net/2142/106649

Copyright and License Information

Copyright 2020 Syeda Tajin Ahmed

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