IMPACT OF THE OH-TO-F REPLACEMENTS IN MONOSACCHARIDES

Alonso, Elena R.

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https://hdl.handle.net/2142/107328 Copy

Description

Title

IMPACT OF THE OH-TO-F REPLACEMENTS IN MONOSACCHARIDES

Author(s)

Alonso, Elena R.

Contributor(s)

Cocinero, Emilio J.; Boutureira, Omar ; Corzana, Francisco ; Basterretxea, Francisco J.; Castillón, Sergio ; Salvadó, Miriam ; Escudero Casao, Margarita ; Mestre, Jordi ; Prieto, Pedro J.; Calabrese, Camilla ; Insausti, Aran

Issue Date

24-Jun-20

Keyword(s)

Conformers and isomers

Abstract

\begin{wrapfigure}{r}{0pt} \includegraphics[scale=0.8]{abstractv4.eps} \end{wrapfigure} Bioisosteric OH-to-F replacements, concretely those produced in saccharides, have become a cornerstone in the development of novel drugs and tracers for the non-invasive imaging modalities, like \mbox{($^{19}$F-MR/MRI)} and ($^{18}$F-PET). F and OH groups are isoelectronic and possess similar polarity and steric impact. Despite its remarkable purposes, there is a lack of knowledge about the structural non-covalent interactions involving F in their native context, which are the key in the activities that they develop. By means of high resolution rotational spectroscopy in combination with a laser ablation\footnote{C. Calabrese, I.Uriarte, A. Insausti, M. Vallejo-López, F.J. Basterretxea, S.A. Cochrane, B.G. Davis*, F. Corzana*, E.J. Cocinero*. \textit{ACS Cent. Sci.} \textbf{2020}, \underline{6}, 2, 293-303}$^{,}$\footnote{C. Calabrese, P. Écija, I. Compañón, M. Vallejo-López, A. Cimas, M. Parra, F.J. Basterretxea, J.I. Santos, J. Jiménez-Barbero, A. Lesarri, F. Corzana*, E.J. Cocinero*. \textit{J. Phys. Chem. Lett.} \textbf{2019}, \underline{10}, 12, 3339-3345}, we are able to isolate and characterize the intrinsic conformational structures of these fluorinated saccharides, obtaining valuable information about their structure and connection with their biological properties.

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

Text

Language

English

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