University of Illinois Urbana-Champaign

Fluid and blood pressure management in maintenance hemodialysis patients

Derk, Gwendolyn

Content Files
DERK-DISSERTATION-2020.pdf

Permalink

https://hdl.handle.net/2142/109503

Description

Title
Fluid and blood pressure management in maintenance hemodialysis patients
Author(s)
Derk, Gwendolyn
Issue Date
2020-12-01
Director of Research (if dissertation) or Advisor (if thesis)
Wilund, Ken
Doctoral Committee Chair(s)
Wilund, Ken
Committee Member(s)
  • Pai, Amy
  • Andrade, Flavia
  • An, Roupeng
Department of Study
Kinesiology & Community Health
Discipline
Community Health
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Date of Ingest
2021-03-05T21:40:47Z
Keyword(s)
Hemodialysis End-Stage Kidney Disease Chronic Kidney Disease Anti Hypertensive Medications Dry Weight Fluid Overload
Abstract
While the majority of the nephrology community would agree that the ideal way to manage the care of a patient on dialysis is through proper volume control strategies, our guidelines and protocols do not reflect these beliefs. The Kidney Disease Outcomes Quality Initiative (KDOQI) has guidelines for treating hypertension in hemodialysis (HD) patients, but it does not provide specific recommendations for managing polypharmacy and deprescribing anti-hypertensive medications. When patients transition from non-dialysis CKD to chronic HD therapy, the requirement for anti-hypertensive medications may change due to the removal of extracellular fluid by ultrafiltration and other factors. Because most blood pressure medications are vasodilators or impact other components of cardiovascular function, they may prevent the normal physiological response to changes in volume during dialysis, leading to intra- or inter-dialytic hypotension, post dialysis fatigue,[1, 2] and a reduced quality of life for patients.[3] Indeed, hypotensive symptoms may occur in more than 20%-50% of dialysis sessions.[1, 4] These symptoms not only make the treatment ineffective or harmful, but also creates a sense of fear in the patients, which makes them resist proposed increases in ultrafiltration volume to achieve or maintain dry weight. Several studies have shown that patients who experience frequent hypotensive events during dialysis have poorer survival.[5, 6] Ultimately, avoiding or minimizing pharmacologic control of blood pressure may facilitate fluid removal and accurate dry weight achievement, which in turn may prevent the myocardial remodeling that is often seen in dialysis patients.[7, 8] This body of work aims to demonstrate the need for and potential eligibility criteria for a comprehensive antihypertensive medication deprescribing protocol in the maintenance hemodialysis population.
Graduation Semester
2020-12
Type of Resource
Thesis
Permalink
http://hdl.handle.net/2142/109503
Copyright and License Information
Copyright 2020 Gwendolyn Derk

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