The Shape Of Levodopa: A Laser Abalation Rotational Study

Novo, Miguel Sanz

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https://hdl.handle.net/2142/111495 Copy

Description

Title

The Shape Of Levodopa: A Laser Abalation Rotational Study

Author(s)

Novo, Miguel Sanz

Contributor(s)

• Alonso, José L.
• León, Iker
• Alonso, Elena R.

Issue Date

2021-06-24

Keyword(s)

Structure determination

Abstract

"The rotational spectrum of neutral levodopa (L-dopa), an aminoacid precursor of neurotransmitters dopamine \footnote{C. Cabezas, I. Pena, J. C. Lopez and J. L. Alonso, J. Phys. Chem. Lett., 2013, 4, 486–490.}, norepinephrine (noradrenaline) and epineophrine (adrenaline), has been investigated for the first time using a broadband chirped pulse FTMW spectrometer coupled with a laser ablation source (LA-CP-FTMW). The spectroscopic parameters derived from the analysis of the spectrum conclusively identify the existence of three conformers of levodopa. The $^{14}$N nuclear quadrupole coupling constants have been analyzed, probing the existence of stabilizing N-H-$\pi$ interactions for the observed structures. \begin{itemize} \item \textbf{Acknowledgments:} The authors thank the financial fundings from Ministerio de Ciencia e Innovacion (CTQ2016-76393-P and PID2019-111396GB-I00), Junta de Castilla y Leon (VA077U16 and VA244P20) and European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC-2013-SyG, Grant Agreement n. 610256 NANOCOSMOS, are gratefully acknowledged. E.R.A. acknowledges MINECO for a Juan de la Cierva postdoctoral fellowship and the Fundación Biofísica Bizkaia (Spain). M.S.N. acknowledges funding from the Spanish ""Ministerio de Ciencia, Innovación y Universidades"" under predoctoral FPU Grant (FPU17/02987). \end{itemize}"

Publisher

International Symposium on Molecular Spectroscopy

Type of Resource

Text

Language

eng

Permalink

http://hdl.handle.net/2142/111495

DOI

10.15278/isms.2021.RK12

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