Cortical bone growth in response to local strain environment

Manandhar, Sony

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https://hdl.handle.net/2142/113933 Copy

Description

Title

Cortical bone growth in response to local strain environment

Author(s)

Manandhar, Sony

Issue Date

2021-12-10

Director of Research (if dissertation) or Advisor (if thesis)

Kersh, Mariana Elizabeth

Department of Study

Mechanical Sci & Engineering

Discipline

Mechanical Engineering

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• cortical
• bone
• growth
• local
• strain

Abstract

Osteoporosis is a disease characterized by skeletal fragility resulting in increased risk of fracture. Millions of people are affected by osteoporotic fractures every year. Pharmaceutical drugs available in the current market have side-effects coming from long-term administration and adherence. While mechanical loading is known to be a critical factor during cortical bone growth, the type of mechanical loading a bone is subjected to during normal physiological condition can also affect bone development process. It still is unclear whether tensile or compressive strains have better outcome in young cortical bone growth. In this study, juvenile sheep femur were scanned using micro-Computed Tomography (CT). Thickness and density were computed via image processing in MATLAB. Bone volume fraction (BV/TV) was determined through image processing in Amira. Samples along the longitudinal axis of diaphysis were machined and mechanically tested in three-point bending. Mechanical testing was done in two con figurations: stain mode specific (SMS) (testing samples in habitual loading) and non-strain mode specific (testing samples in loading they are normally subjected to). Structure, composition, and material properties were investigated in two specific quadrants of femur diaphysis: anterior side subjected to tensile loading, and posterior side subjected to compressive loading during physiological activities. There was no significant difference between cortical thickness and density of anterior and posterior quadrants. BV/TV was significantly higher in anterior quadrant compared to posterior quadrant in proximal diaphysis (p=0.016). Flexural modulus of anterior quadrant was higher than posterior only in distal diaphysis when tested in non-SMS condition (p=8E- 3). Anterior quadrant was always stronger than posterior quadrant regardless of testing mode (SMS: p=8E-3 proximal and middle diaphysis, non-SMS: p=8E-3 middle and distal diaphysis). Poor correlation was detected between density-modulus and density-strength (R2 = 7.6% and R2 = 11.3% respectively). BV/TV was more important in explaining the material properties than density: BV/TV-modulus R2 = 10.7% and BV/TV-strength R2 = 30.7%.

Graduation Semester

2021-12

Type of Resource

Thesis

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http://hdl.handle.net/2142/113933

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Copyright 2021 Sony Manandhar

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