Withdraw
Loading…
Characterizing the targets of dysregulated microRNAs in colorectal cancer
Ghaffari, Saba
Content Files

Loading…
Download Files
Loading…
Download Counts (All Files)
Loading…
Edit File
Loading…
Permalink
https://hdl.handle.net/2142/114107
Description
- Title
- Characterizing the targets of dysregulated microRNAs in colorectal cancer
- Author(s)
- Ghaffari, Saba
- Issue Date
- 2021-12-08
- Director of Research (if dissertation) or Advisor (if thesis)
- Sinha, Saurabh
- Department of Study
- Computer Science
- Discipline
- Computer Science
- Degree Granting Institution
- University of Illinois at Urbana-Champaign
- Degree Name
- M.S.
- Degree Level
- Thesis
- Date of Ingest
- 2022-04-29T21:58:40Z
- Keyword(s)
- MicroRNA, Colorectal Cancer, Gene set characterization
- Abstract
- Dysregulated microRNAs have been largely associated with tumorigenesis and cancer invasion. Therefore, identifying their direct/indirect targets is crucial to study the cellular processes that are altered as a result of microRNA dysregulation. In this thesis, we aim to identify the targets of dysregulated microRNAs in colorectal cancer progression by adapting a network-guided gene set characterization technique in which prior biological knowledge can be utilized to find novel molecular associations. Further analysis of the targets found by our approach revealed a protein complex that has been proposed as a therapeutic target for inhibiting colorectal cancer in recent studies.
- Graduation Semester
- 2021-12
- Type of Resource
- Thesis
- Permalink
- http://hdl.handle.net/2142/114107
- Copyright and License Information
- Copyright 2021 Saba Ghaffari
Owning Collections
Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at IllinoisManage Files
Loading…
Edit Collection Membership
Loading…
Edit Metadata
Loading…
Edit Properties
Loading…
Embargoes
Loading…