Characterizing the targets of dysregulated microRNAs in colorectal cancer

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https://hdl.handle.net/2142/114107

Title: Characterizing the targets of dysregulated microRNAs in colorectal cancer
Author(s): Ghaffari, Saba
Issue Date: 2021-12-08
Director of Research (if dissertation) or Advisor (if thesis): Sinha, Saurabh
Department of Study: Computer Science
Discipline: Computer Science
Degree Granting Institution: University of Illinois at Urbana-Champaign
Degree Name: M.S.
Degree Level: Thesis
Date of Ingest: 2022-04-29T21:58:40Z
Keyword(s): Computer science
Language: eng
Abstract: Dysregulated microRNAs have been largely associated with tumorigenesis and cancer invasion. Therefore, identifying their direct/indirect targets is crucial to study the cellular processes that are altered as a result of microRNA dysregulation. In this thesis, we aim to identify the targets of dysregulated microRNAs in colorectal cancer progression by adapting a network-guided gene set characterization technique in which prior biological knowledge can be utilized to find novel molecular associations. Further analysis of the targets found by our approach revealed a protein complex that has been proposed as a therapeutic target for inhibiting colorectal cancer in recent studies.
Graduation Semester: 2021-12
Type of Resource: Thesis
Permalink: http://hdl.handle.net/2142/114107