Topographic AFM Image of DNA Nanostructure (Virus Fishing Net)
Xiong, Yanyu
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https://hdl.handle.net/2142/114305
Description
Title
Topographic AFM Image of DNA Nanostructure (Virus Fishing Net)
Author(s)
Xiong, Yanyu
Contributor(s)
Xiong, Yanyu
Issue Date
2022
Keyword(s)
ECE
Abstract
The AFM (atomic force microscopy) image shows a topographic surface for a two-dimensional DNA tile-based nanostructure self-assembled with synthetic DNA oligonucleotides with programmed sequences. This is a designed DNA nanostructure-based capture probe that harbors a macromolecular “net” (60nm*60nm) whose vertices match the intra- and inter-spatial patterns of the trimeric spike glycoprotein on SARS-CoV-2 virions that can arrange external elements with nanometer-scale accuracy for different applications. Image provided by Yanyu Xiong from Prof. Brian Cunningham's group. Dr. Neha Chauhan from Prof. Xing Wang's group also helped with sample preparation.
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