Active matter for removal of biofilm and endocrine-disrupting chemicals
Deng, Yu-Heng
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https://hdl.handle.net/2142/115887
Description
Title
Active matter for removal of biofilm and endocrine-disrupting chemicals
Author(s)
Deng, Yu-Heng
Issue Date
2022-07-06
Director of Research (if dissertation) or Advisor (if thesis)
Kong, Hyunjoon
Doctoral Committee Chair(s)
Kong, Hyunjoon
Committee Member(s)
Boppart, Stephen A
Flaherty, David W
Kraft, Mary L
Department of Study
Chemical & Biomolecular Engr
Discipline
Chemical Engineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Biofilm
BPA
Language
eng
Abstract
Biofilm and endocrine-disrupting chemicals are critical environmental problems that impact human’s health. Although a number of strategies have been proposed to address these issues, the recurrence of biofilm and endocrine-disrupting chemicals in the environment keep exerting adverse effects on our daily lives. To this end, the overall goal of my research is to develop a system of active matter for the removal of biofilm and endocrine-disrupting chemicals. In this dissertation, Chapter 1 discusses the methodologies of active matter fabrication, the fundamental issues caused by biofilm and endocrine-disrupt chemicals, and the current constraints in the removal of these two issues. Chapter 2 presents the design of active matter, so-called self- locomotive, antimicrobial microrobot (SLAM), and explains its mechanism to eliminate biofilm from target bio-fouled structures. Based on the findings in Chapter 2, Chapter 3 investigates how to prevent biofilm recurrence by constructing a collective analysis to understand the biofilm composition. Chapter 4 further explores how SLAM can be applied as a micro-cleaner to remove endocrine-disrupting chemicals through its intrinsic oxidation capability, along with in vitro studies that examines the toxicity of endocrine-disrupting chemicals after the treatments. Lastly, Chapter 5 summarizes the key findings through Chapter 2 to Chapter 4 and proposes the directions for future investigations.
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