Joint-optimization of the x-ray source voltage, beam filtration and detection angle for a full-ring benchtop x-ray fluorescence computed tomography (XFCT) image system
Nie, Xingchen
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https://hdl.handle.net/2142/116165
Description
Title
Joint-optimization of the x-ray source voltage, beam filtration and detection angle for a full-ring benchtop x-ray fluorescence computed tomography (XFCT) image system
Author(s)
Nie, Xingchen
Issue Date
2022-07-08
Director of Research (if dissertation) or Advisor (if thesis)
Meng, Lingjian
Committee Member(s)
Di Fulvio, Angela
Department of Study
Nuclear, Plasma, & Rad Engr
Discipline
Nuclear, Plasma, Radiolgc Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
X-Ray
XFCT
Fluorescence
signal-to-noise
Language
eng
Abstract
In this thesis, we present a combined theoretical and Monte Carlo study to optimize the design of a full-ring desktop X-Ray Fluorescence Computed Tomography (XFCT) system based on ultrahigh energy resolution CdTe detectors and a pencil-beam-irradiation/multiple-slit camera (PB/MS) geometry. In this study, we have specifically focused on a joint-optimization of X-ray source voltage, beam filtering and signal-collection angle for improving the signal-to-noise ratio attainable with the imaging setup. Given a large number of possible combinations of these design parameters, we have developed an analytical approach that could be used to rapidly evaluate the intrinsic signal-to-noise ratio (SNR) that measures the fluorescence signal, Compton scattering noise, and Rayleigh scattering noise generated under a simplified X-ray irradiation and data collection geometry. We have used this method to search through a large number (a total of 4800 in this study) of different combinations of system parameters, such as X-ray tube voltage, filter material, thickness, angle of detection, etc., to identify the potential optimum choice of system parameters. The study shows the following two conclusions, (1) If the dose is the primary concern, the value of the SNR improved with an increased filter thickness and a large back-ward signal collection angle, (2) Given the X-ray tube maximum power, the maximum tube voltage with a signal collection angle of 80-100 degrees can reach the optimum SNR. These results were further validated through Monte Carlo studies with more realistic imaging geometries.
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