From the ocean to the operating room: translating single-sensor spectral imagers to image-guided cancer surgery

Blair, Steven Michael

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https://hdl.handle.net/2142/117590 Copy

Description

Title

From the ocean to the operating room: translating single-sensor spectral imagers to image-guided cancer surgery

Author(s)

Blair, Steven Michael

Issue Date

2022-12-02

Director of Research (if dissertation) or Advisor (if thesis)

Gruev, Viktor

Doctoral Committee Chair(s)

Gruev, Viktor

Committee Member(s)

• Cunningham, Brian T.
• Nie, Shuming
• Oelze, Michael L.

Department of Study

Electrical & Computer Eng

Discipline

Electrical & Computer Engr

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

• Image-guided surgery
• Intraoperative imaging
• Optical imaging
• Spectral imaging
• Fluorescence imaging
• Molecular imaging
• CMOS image sensor
• Bioinspired design
• Stacked photodiode image sensor
• Pixelated interference filters
• Demosaicing algorithm
• Prostate cancer and breast cancer
• Tumor detection and classification
• Sentinel lymph node mapping and biopsy

Abstract

Nature has long served to remind humankind of all that is possible beyond their own capabilities. For instance, the mantis shrimp’s compound eye, constructed from interleaved layers of light-absorbing pigments and photosensitive cells, can see upwards of 12 different colors spanning the optical spectrum, whereas the human eye, constructed from a single layer of photosensitive cells, can see just three different colors confined solely to the visible spectrum. Such inspiration is in no less demand as scientists, engineers, and doctors alike look to finally do what has long been considered impossible—to cure cancer once and for all. In this way, the mantis shrimp’s extraordinary ability to make visible what most humans would say is invisible might serve as a model for the surgeon who must distinguish, from the subtle signs that make treatment so difficult, the cancerous tissue that must be removed for a patient to be put into remission and the healthy tissue that should be retained for a patient to be spared lifelong side effects. This dissertation proposes a new approach to surgical systems that seeks to translate the evolutionary design that has enabled the mantis shrimp to thrive in the ocean into a product of engineering that can empower surgeons to make the tough decisions they face in the operating room. It then demonstrates, through the development of a hexachromatic bio-inspired camera for image-guided cancer surgery and the evaluation of related single-sensor spectral imagers capable of detecting more cancers with greater sensitivity, that such an approach can already make a difference in prostate cancer and breast cancer—and could continue to improve outcomes for all those impacted by cancer’s scourge.

Graduation Semester

2022-12

Type of Resource

Thesis

Copyright and License Information

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