Evaluation of functional ingredients on glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in companion animal nutrition

Kayser, Emanuela

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https://hdl.handle.net/2142/122141 Copy

Description

Title

Evaluation of functional ingredients on glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in companion animal nutrition

Author(s)

Kayser, Emanuela

Issue Date

2023-11-30

Director of Research (if dissertation) or Advisor (if thesis)

C. de Godoy, Maria R

Doctoral Committee Chair(s)

Steelman, Andrew

Committee Member(s)

• Swanson, Kelly S.
• Rodriguez-Zas, Sandra
• Fahey, George

Department of Study

Nutritional Sciences

Discipline

Nutritional Sciences

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

Ph.D.

Degree Level

Dissertation

Keyword(s)

Canine nutrition, functional ingredients

Abstract

The primary role of the canine diet is to provide sufficient nutrients to meet the metabolic requirements of dogs. More recently, however, a hypothesis has been supported that, beyond meeting nutritional needs, diet may modulate several functions in the body, which could contribute to reducing the risk of diseases. The use of functional ingredients has contributed to product diversification and the ability to support functional and structural claims in commercial pet foods. These may include weight management or maintenance, skin and coat health, gastrointestinal health, joint health, and more. This dissertation aimed to evaluate the effects of selected functional ingredients in glycemic response, fecal metabolites, fecal microbiota, systemic oxidative stress and inflammation, and nutrient digestibility in healthy adult dogs. The first aim was to evaluate the longitudinal effects of daily supplementation of Bifidobacterium animalis subsp. lactis CECT 8145 live and heat-killed on weight management, fecal fermentative end-products and microbiota, insulin sensitivity, gut hormones, oxidative stress, inflammatory markers, and white blood cell gene expression of adult dogs. The second aim was to evaluate the effects of dietary inclusion of Ganoderma lucidum (GL) on peripheral blood mononuclear cells (PBMC; T-cells, B-cells, monocytes, and natural killers), vaccine response, nutrient digestibility, fecal fermentative end-products and microbiota, and skin and coat quality of adult dogs. The third aim was to evaluate the longitudinal effects of daily supplementation of incremental doses of inositol on serum oxidative stress, inflammatory biomarkers, gut hormones, and postprandial glycemic and insulinemic responses in overweight dogs. Overall, our results demonstrate that the supplementation of the listed functional ingredients had no detrimental effects to the health status of the dogs. Additionally, the probiotic supplemented appears to influence gene expression for energy metabolism. Due to changes in immune parameters among treatments, GL may exert beneficial immunomodulatory effects in healthy adult dogs when provided at a daily dose of 15 mg/kg BW. We also observed that longitudinal supplementation of inositol may interact with inflammatory response and contribute to the regulation of glucose metabolism.

Graduation Semester

2023-12

Type of Resource

Thesis

Handle URL

https://hdl.handle.net/2142/122141

Copyright and License Information

Copyright 2023 Emanuela Kayser

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