How bitter is it? Odor induced taste modulation of bitter ligands

Hall, Leah

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https://hdl.handle.net/2142/124519 Copy

Description

Title

How bitter is it? Odor induced taste modulation of bitter ligands

Author(s)

Hall, Leah

Issue Date

2024-04-26

Director of Research (if dissertation) or Advisor (if thesis)

Pepino , Yanina

Committee Member(s)

• Cadwallader, Keith
• Miller, Michael

Department of Study

Food Science & Human Nutrition

Discipline

Food Science & Human Nutrition

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• Bitter
• Retronasal
• Chemesthetic

Language

eng

Abstract

The presence of bitter compounds in healthy foods and pharmaceuticals can steer people away from products that benefit health. The examination of bitter taste is especially complex due to the varying taste phenotypes present in our population and the ability of one bitter ligand to activate multiple receptors. Several factors, including concentration of stimuli, expectation biases, and blocking of nasal pathways can alter the overall flavor and basic taste perception, making it crucial to translate cellular assays to in-vivo models. This study aims to better understand retronasal olfaction and chemesthetic irritation mechanisms of bitter taste to pharmaceutical and food-grade ligands utilizing a panel of healthy adults who scored the bitterness and irritation of suprathreshold concentrations of nine stimuli with and without nose clips. The study used duplicate taste intensity ratings from 47 participants who were trained to use the general labeled magnitude scale (gLms). Participants rated the smell, irritation, overall flavor, and the like/dislike experienced for most compounds. Out of the nine agonists (Naringin 10/50/100mM, Ibuprofen sodium 10/44/100mM, Theobromine 1/10/30m, Acesulfame K 1/12/100mM, Sodium Benzoate 50/100/300mM, Acetaminophen 1/10/100mM, Propylthiouracil 0.056/0.18/0.56 mM, Dextromethorphan 0.01/0.1/1mM, and Diphenhydramine 0.5/1/10 mM) only the Naringin showed change in bitterness ratings based on nose clip condition at the highest concentration, with the presence of retronasal olfaction decreasing bitter perception (p=0.005). Ibuprofen (p=0.01) and Theobromine (p=0.03) were the two compounds to show significant differences in irritation ratings based on nose-clip condition. For both Theobromine and Ibuprofen, ratings for irritation increased without the nose clip proportionally to the concentration

Graduation Semester

2024-05

Type of Resource

Text

Handle URL

https://hdl.handle.net/2142/124519

Copyright and License Information

Copyright 2024 Leah Hall

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