A portable, smartphone-linked, and miniaturized photonic resonator absorption microscope (PRAM MINI) for point-of-care diagnostics
Khemtonglang, Sydney
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https://hdl.handle.net/2142/124586
Description
Title
A portable, smartphone-linked, and miniaturized photonic resonator absorption microscope (PRAM MINI) for point-of-care diagnostics
Author(s)
Khemtonglang, Sydney
Issue Date
2024-05-01
Director of Research (if dissertation) or Advisor (if thesis)
Cunningham, Brian T
Department of Study
Bioengineering
Discipline
Bioengineering
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
M.S.
Degree Level
Thesis
Keyword(s)
Photonic Crystals Biosensor
Absorption Microscopy
Point-of-care Diagnostics
Language
eng
Abstract
Point-of-care testing (POCT) has revolutionized healthcare with its rapid, accurate, and all-in-one diagnostic capabilities. In this work, we report the development and validation of the miniaturized Photonic Resonator Absorption Microscope (PRAM Mini), integrated wirelessly with a smartphone application. PRAM Mini harnesses the unique optical coupling of photonic crystal (PC) guided-mode resonance and gold nanoparticle (AuNP) localized surface plasmon resonance to achieve a significant reduction in reflected PC intensity caused by the localized quenching of the AuNP. As an initial demonstration, PRAM Mini effectively detects SARS-CoV-2 antibodies in clinical samples using a blocking biosensor assay. PRAM Mini offers a compact and cost-effective solution for point-of-care diagnostics with text-book-sized dimensions of 23 cm × 21 cm × 10 cm and a total cost of $2,111.65. Its digital resolution quantification features and smartphone-linked functionality enhance accessibility and usability in diverse healthcare settings. The PRAM Mini is a promising tool for addressing the increasing demand for portable and efficient diagnostic solutions, contributing significantly to improved patient care and healthcare system efficiency.
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