Biomimetic antimicrobial polymer films and their biomedical and food-packaging applications
Zhang, Yi
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https://hdl.handle.net/2142/124631
Description
Title
Biomimetic antimicrobial polymer films and their biomedical and food-packaging applications
Author(s)
Zhang, Yi
Issue Date
2024-03-25
Director of Research (if dissertation) or Advisor (if thesis)
Cao, Qing
Doctoral Committee Chair(s)
Cao, Qing
Committee Member(s)
Lau, Gee
Wang, Hua
Leal, Cecilia
Department of Study
Materials Science & Engineerng
Discipline
Materials Science & Engr
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Antimicrobial Materials
Nanoscale Fabrication
Biomedical Devices
Food Packaging Materials
Language
eng
Abstract
In this project, we utilize an innovative approach combining antibacterial nanostructures with high-resolution strain mapping sensor arrays to address orthopedic complications, such as periprosthetic infections and mechanical failures of implants. Initially, our research focuses on employing nanosphere lithography to create antibacterial surfaces. This method allows for precise control over the physical parameters of nanopillar array, facilitating studies that led to a robust understanding of the bactericidal mechanisms involved. Through iterative testing, we enhanced the antibacterial efficacy of these structures. Subsequently, we adopted the anodic aluminum oxide (AAO) template method to scale up nanopillar structure fabrication, demonstrating its potential in food packaging applications. Alongside, we innovated strain sensors for orthopedic implants. By employing transfer printing techniques, we developed ultrathin silicon-based sensors on flexible substrates, creating a comprehensive strain sensing array. This innovation, intended for spine fusion monitoring, also incorporates Bluetooth Low Energy (BLE) technology for wireless, real-time clinical monitoring. In conclusion, this project pioneers significant advancements in both antibacterial structures and strain mapping sensor arrays, offering a new direction for the development of electronic medical applications. These innovations not only address current orthopedic challenges but also lay the groundwork for future technological breakthroughs in medical devices.
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