Circadian rhythmicity of rat neuroendothelial cells at the blood-brain interface
Weiss, Amanda C
Loading…
Permalink
https://hdl.handle.net/2142/125600
Description
Title
Circadian rhythmicity of rat neuroendothelial cells at the blood-brain interface
Author(s)
Weiss, Amanda C
Issue Date
2024-07-11
Director of Research (if dissertation) or Advisor (if thesis)
Gillette, Martha U
Doctoral Committee Chair(s)
Gillette, Martha U
Committee Member(s)
Kong, Hyunjoon
Chung, Hee Jung
Sweedler, Jonathan V
Department of Study
Molecular & Integrative Physl
Discipline
Molecular & Integrative Physi
Degree Granting Institution
University of Illinois at Urbana-Champaign
Degree Name
Ph.D.
Degree Level
Dissertation
Keyword(s)
Blood-brain Barrier
Circadian Rhythms
Blood-brain Interface
Blood-brain Barrier Permeability
Language
eng
Abstract
The Blood-Brain Interface (BBI) facilitates neurological protection from pathogens, the removal of waste products, brain homeostasis, and the permeation of nutrients and drugs. Its dysfunction contributes to the onset of a variety of neurological diseases, including strokes and dementia. Research has shown that both BBI permeability and human susceptibility to strokes fluctuate according to time of day. However, more in vitro studies are required to isolate the effects of circadian rhythms from the effects of sleep and other confounding factors on BBI permeability. The role of neuroendothelial cells, a key component of the BBI, has also not been fully elucidated. We have determined that barrier tightness and permeability oscillate according to time of day in rat neuroendothelial cells. These findings extended to permeability to the blood clotting factor fibrinogen. We also determined that the addition of Carbachol, a pan-acetylcholine receptor agonist, could shift these rhythms.
Use this login method if you
don't
have an
@illinois.edu
email address.
(Oops, I do have one)
IDEALS migrated to a new platform on June 23, 2022. If you created
your account prior to this date, you will have to reset your password
using the forgot-password link below.
