Innovative and traditional approaches to research curation on diet, microbiome, and health

Hindle, Veronica Kate

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https://hdl.handle.net/2142/125833 Copy

Description

Title

Innovative and traditional approaches to research curation on diet, microbiome, and health

Author(s)

Hindle, Veronica Kate

Issue Date

2024-07-18

Director of Research (if dissertation) or Advisor (if thesis)

Holscher, Hannah D

Committee Member(s)

• Kilicoglu, Halil
• Miller, Michael J

Department of Study

Food Science & Human Nutrition

Discipline

Food Science & Human Nutrition

Degree Granting Institution

University of Illinois at Urbana-Champaign

Degree Name

M.S.

Degree Level

Thesis

Keyword(s)

• dietary interventions
• gut microbiota
• probiotics
• prebiotics

Abstract

Nutrition is essential in maintaining health and improving or preventing disease. Nutrition and microbiome research has escalated in recent years, with increasing interest from consumers in diet-microbiota interactions. Recent technological advancements have allowed this area of research to further expand into the personalized nutrition domain to better understand the relationships between diet, microbiota, and well-being at the individual level. Traditionally, probiotic lactic acid bacteria, such as Lactobacillus spp. and Bifidobacterium spp., are safe for human consumption and help alleviate various health conditions. Over the past decade, the microbiome industry has expanded and created new technologies, including bioinformatics, next-generation sequencing, complete genome sequencing, and culture techniques. These technologies have allowed scientists to discover novel bacterial strains that may have applications as next-generation probiotics. Concurrently, studies are increasingly revealing how certain dietary patterns, foods, and nutrients nourish the intestinal microbiota, which has implications for expanding substrates that may qualify as prebiotics. The objectives of this current research were to summarize microbiota-focused dietary interventions in relation to human health and enhance text mining on diet, the gastrointestinal microbiome, and health from the current literature. Both research foci investigated areas of cutting-edge disciplines within the nutrition and microbiome landscape. Herein, we review the current scientific literature and present novel findings from our original research. The findings of these studies highlight the associations between diet, the gastrointestinal microbiome, and health. Overall, this work has implications for biotic-focused research on candidate prebiotic substrates as well as next-generation probiotics.

Graduation Semester

2024-08

Type of Resource

Thesis

Handle URL

https://hdl.handle.net/2142/125833

Copyright and License Information

Copyright 2024 Veronica Hindle

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