Current Research Pertaining to the Correlation of Prion Proteins and Alzheimer's Disease
Chitimilla, Rikhil
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https://hdl.handle.net/2142/126456
Description
Title
Current Research Pertaining to the Correlation of Prion Proteins and Alzheimer's Disease
Author(s)
Chitimilla, Rikhil
Issue Date
2023
Keyword(s)
Alzheimer's Disease
prion proteins
amyloid cascade hypothesis
Date of Ingest
2025-03-13T20:35:45-05:00
Abstract
At present, there are around 50 million AD patients worldwide and this number is projected to double every 5 years and will increase to reach 152 million by 2050. (National Library of Medicine). This neurodegenerative disease has been known to cause cognitive impairment and memory loss. In recent research ti seems that this degenerative disease is being correlated with the accumulation of the amyloid-beta (Aß) peptide as well as the prion protein ( P r C ) . (PrPC) has been discovered to have inhibitory properties on the Beta-Secretase enzyme (BACE1). The inhibition of BACE1 leads to the essential deprivation of the rate-limiting step, which results in the increase of amyloid-beta.
Publisher
University of Illinois Undergraduate Neuroscience Society
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