History of chemistry in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Kirk, Kenneth L.

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https://hdl.handle.net/2142/127899 Copy

Description

Title

History of chemistry in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Author(s)

Kirk, Kenneth L.

Contributor(s)

Jacobson, Kenneth A.

Issue Date

2014-09-15

Keyword(s)

• History
• Chemistry
• History chem national institute diabetes digestive kidney diseases niddk

Abstract

The origins of the Lab. of Bioorg. Chem., NIDDK, NIH can be traced to events that occurred in the early 20th century. From its beginning to the present, as the lab. evolved through several organizational changes, many important historical contributions to org. chem. and biochem. were made. For example, its early precursor, the Division of Chem. of the Hygienic Lab., was assigned the responsibility of safeguarding public health by analyzing environmental and other chem. risks. This review will trace important developments from the early 20th century to the present. The topics covered in this review include a historical synopsis, early work on receptors, carbohydrates, heterocycles and nucleotides, with specific emphasis on frog skin alkaloids, the NIH shift (a transfer of an arom. hydrogen atom to a neighboring ring position during ring hydroxylation, important in the biochem. processing of arom. substrates), the methionine-specific cleavage of proteins using cyanogen bromide (used com. and in peptide research) as well as other fundamental contributions. Ongoing research in medicinal chem., natural products, biochem., vaccines and pharmacol., some leading to clin. applications, will be discussed.

Publisher

Division of the History of Chemistry

ISSN

1053-4385

Type of Resource

text

Genre of Resource

article

Language

eng

Permalink

https://hdl.handle.net/2142/127899

DOI

https://doi.org/10.70359/bhc2014v039p150

Copyright and License Information

Copyright 2014 Division of the History of Chemistry

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