Structural Resonance: The Harmony of a Triangular Liver Organoid

Zobus, Katie

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https://hdl.handle.net/2142/128157 Copy

Description

Title

Structural Resonance: The Harmony of a Triangular Liver Organoid

Author(s)

Zobus, Katie

Issue Date

2025

Keyword(s)

• triangle
• liver
• organoid

Date of Ingest

2025-05-08T12:08:00-05:00

Abstract

Triangles hold significance across human experience: a shape first learned in childhood, a symbol of balance and trinity, and a foundational form for engineers pursuing structural soundness. Reflected in biological design, the liver is composed of lobules, which are hexagonal structures fundamentally built from triangles. This image reveals a construct of a Z-stack of a triangular stem cell-derived liver organoid. Organoids are in vitro three-dimensional tissues derived from cell culture to model organs for disease modeling and drug screening.The fluorescent palette of each organoid tells a cellular story: the red stain is indicative of hepatocytes, the liver's primary cell type, while the outer green traces the network of cholangiocytes that form the bile ducts to assist in digestion. Through our research of organoid development and maturation by varying geometries, the triangular form has materialized as a paradigm of stability, where its three pillars mirror the strength that makes this geometric shape a basis of both nature and human design.

Type of Resource

• still image
• text

Language

eng

Copyright and License Information

Copyright 2025 Katie Zobus

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