Regenerating disc of the SUPERFLY

Mathure, Snigdha Amit

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https://hdl.handle.net/2142/132900 Copy

Description

Title

Regenerating disc of the SUPERFLY

Author(s)

Mathure, Snigdha Amit

Issue Date

2023

Keyword(s)

Cell and Developmental Biology

Abstract

The organs that enable fruit flies to roam around bananas are wings and wing-imaginal discs. The wing discs are present in fruit fly larvae, forming the adult fly wings. These imaginal discs have the superpower of regenerating after damage. At the Smith-Bolton lab, we study how damaged tissue regenerates using the fruit fly as a model. Here, the picture depicts the genetic damage-inducing system developed by Dr. Smith-Bolton, in the larval wing disc. The first image, to the left, shows the cellular networks stained with actin in red. The second image is an overlay of actin with distinct cell nuclei, as seen in blue. The following image shows dying cells in green, which is possible by our genetic damage system, where we can selectively cause cell death within the wing disc. Through this, we can study the nature of the tissue when damage is induced, and in-turn, study regeneration as the tissue heals inside the fruit-fly larvae. The fourth image depicts an overlay of all three images. Throughout the process of damage and regeneration, all the green dying cells are eventually replaced by blue, living cells enabling us to study the what’s, why’s, and how’s of wing imaginal disc regeneration.

Type of Resource

• Text
• Image

Language

eng

Handle URL

https://hdl.handle.net/2142/132900

Copyright and License Information

Copyright 2023 Snigdha Amit Mathure

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