ALLYLIC C-H AMINATION OF TERMINAL OLEFINS WITH PRIMARY AMINES VIA TRANSITION METAL CATALYSIS

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https://hdl.handle.net/2142/133172

Title: ALLYLIC C-H AMINATION OF TERMINAL OLEFINS WITH PRIMARY AMINES VIA TRANSITION METAL CATALYSIS
Author(s): Kurak, Justin
Issue Date: 2026-05-13
Director of Research (if dissertation) or Advisor (if thesis): White, M. Christina
Date of Ingest: 2026-05-13T10:42:33-05:00
Keyword(s): AMINATION, C-H ACTIVATION, SELECTIVITY
Language: eng
Abstract: Secondary amines represent roughly 20% of bioactive molecules. However, accessing secondary amines in a late stage setting in a practical sense is an unfortunately inefficient process. Alkylation of primary amines typically generate a more nucleophilic product hence selectivity for the secondary amine is difficult. Furthermore, catalytic methods for C-N bond formation reactions can be inhibited by sterically unhindered basic amines given the electrophilic nature of the metal species. A practical and selective C-N bond forming reaction would be incredibly useful in streamlining pharmaceutical screening and molecular synthesis. Herein, we seek to address the pitfalls of secondary amine synthesis by utilizing a palladium-mediated allylic cross-coupling to furnish a formal C-N bond formation between primary amines and terminal olefins.
Type of Resource: text

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