Withdraw
Loading…
Comparison of two different methods to detect telomerase activity in normal and neoplastic lymph nodes in the dog
Valentini, Fabio
Content Files

Loading…
Download Files
Loading…
Download Counts (All Files)
Loading…
Edit File
Loading…
Permalink
https://hdl.handle.net/2142/16707
Description
- Title
- Comparison of two different methods to detect telomerase activity in normal and neoplastic lymph nodes in the dog
- Author(s)
- Valentini, Fabio
- Issue Date
- 2010-08-20T17:55:32Z
- Director of Research (if dissertation) or Advisor (if thesis)
- Kitchell, Barbara E.
- Department of Study
- Vet Clinical Medicine
- Discipline
- VMS-Veterinary Clinical Medcne
- Degree Granting Institution
- University of Illinois at Urbana-Champaign
- Degree Name
- M.S.
- Degree Level
- Thesis
- Date of Ingest
- 2010-08-20T17:55:32Z
- Keyword(s)
- telomere
- telomerase
- lymphoma
- dog
- Abstract
- One of the several differences between a normal and a neoplastic cell is that there is a phisiological limit to the number of possible cell replications in the former, whereas it appears to be unlimited in the latter. For this reason, cancer cells are thought to undergo a phenomenon of immortalization. The chromosome extremities contain structurally defined elements called telomeres. In normal somatic cells, each mitotic cycle leads to a reduction of telomere lenght until a critical point is reached. Telomere erosion to this critical lenght presents a signal for the cell to arrest further divisions and to undergo cellular senescence or to activate apoptosis. Telomeres that avoid critical shortening could, theoretically, replicate endlessly, thereby immortalizing the cell. One mechanism to restore telomere lenght is the activation of a specific reverse transcriptase called telomerase. The telomerase is a ribonucleoprotein that contains a 9-base-pair RNA template to rapidly construct telomeric repeats. Upregulation of the telomerase enzyme provides immortalizing capacity to neoplastic cells. Based on the hypothesis that telomerase is a specific marker of neoplastic tissues, the development of methods to detect its activity may represent an accurate, non-invasive diagnostic and prognostic tool.
- Graduation Semester
- 2010-08
- Permalink
- http://hdl.handle.net/2142/16707
- Copyright and License Information
- Copyright 2010 Fabio Valentini
Owning Collections
Graduate Dissertations and Theses at Illinois PRIMARY
Graduate Theses and Dissertations at IllinoisManage Files
Loading…
Edit Collection Membership
Loading…
Edit Metadata
Loading…
Edit Properties
Loading…
Embargoes
Loading…